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活体供体-赠送同种异体移植物结石:结石切除和随访后的手术经验。

Living donor-gifted allograft lithiasis: surgical experience after bench surgery stone removal and follow-up.

机构信息

Division of Kidney Transplant, Department of Urology, Hospital Clinic, Barcelona, Spain.

Division of Transplant Surgery, Department of General Surgery, Hospital General Plaza de la Salud, Santo Domingo, Dominican Republic.

出版信息

Urolithiasis. 2023 Jun 26;51(1):91. doi: 10.1007/s00240-023-01463-1.

Abstract

This study presents the surgical experience and long-term outcomes of living donor kidney transplantations involving asymptomatic kidney stones, using ex vivo flexible ureterorenoscopy (f-URS) during bench surgery for stone removal. Out of 1743 living kidney donors assessed between January 2012 and October 2022, 18 (1%) were diagnosed with urolithiasis. Among them, 12 donors were rejected, and 6 were accepted for kidney donation. Stone removal was successfully performed using f-URS during bench surgery, with no immediate complications or acute rejections observed. The study analyzed six living kidney transplants, of which 4 (67%) donors and three recipients were female, and 4 (67%) donors were blood-related to the recipient. The median age for donors and recipients was 57.5 and 51.5 years, respectively. The stones, primarily located in the lower calyx, had a median size of 6 mm. The median cold ischemia time during surgery was 41.6 min, and ex vivo f-URS ensured complete stone removal in all cases. After a median follow-up of 120 months, the remaining grafts were functioning well, and no urinary stone recurrence was observed in either the recipients or living donors. The findings suggest that bench f-URS is a safe approach for managing urinary stones in kidney grafts, providing good functional outcomes without stone recurrence in selected cases.

摘要

本研究介绍了在体外使用软性输尿管镜(f-URS)进行碎石术的活体供肾移植中,处理无症状肾结石的手术经验和长期结果。在 2012 年 1 月至 2022 年 10 月期间评估的 1743 名活体肾脏供体中,有 18 名(1%)被诊断为尿路结石。其中,有 12 名供体被拒绝,6 名供体被接受进行肾脏捐献。在体外使用 f-URS 成功地进行了碎石术,没有观察到即时并发症或急性排斥反应。该研究分析了 6 例活体肾移植,其中 4 名(67%)供体和 3 名受体为女性,4 名(67%)供体与受体有血缘关系。供体和受体的中位年龄分别为 57.5 岁和 51.5 岁。结石主要位于下盏,中位大小为 6 毫米。手术中冷缺血时间的中位数为 41.6 分钟,体外 f-URS 确保了所有病例都能完全清除结石。中位随访 120 个月后,其余移植物功能良好,受体和活体供体均未出现结石复发。研究结果表明,体外 f-URS 是处理移植肾中肾结石的一种安全方法,在选择的病例中提供了良好的功能结果,且无结石复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eeb1/10293412/ddf34cf8281a/240_2023_1463_Fig1_HTML.jpg

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