Alsanosi Safaa M, Mousa Ahmed H, Ahmadini Hind A, Qadhi Rawabi S, Ikram Nadeem, Felemban Alaa H, Alqashqri Hamsah S, Hariri Nahla H, Alhindi Yosra Z, Ayoub Nahla
Department of Pharmacology and Toxicology.
Institute of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom.
Ann Med Surg (Lond). 2023 May 10;85(6):2545-2549. doi: 10.1097/MS9.0000000000000818. eCollection 2023 Jun.
Saudi Arabia has several hypertensive patients who require close attention and specialised care for their medications. Polypharmacy is one of the reasons for the failure of patient compliance with antihypertensive medications. Therefore, this study aims to gain a better perspective on polypharmacy in hypertensive patients attending primary healthcare (PHC) centres in Makkah, Saudi Arabia.
This was an observational, cross-sectional, descriptive study of hypertensive patients followed up at 10 PHC centres in Makkah, Saudi Arabia, from 1 July 2019 to 30 June 2022. Frequencies and percentages were used to present categorical data, and Pearson's test was used to measure differences. A value less than 0.05 was considered statistically significant.
A total of 506 patients were included in this study. The mean age of the patients was 60 years, and more than half (69%) were females. Regarding antihypertensive medication use, 64% were on antihypertensive combination therapy, 76% on dual therapy, 21% on triple therapy, and 3% on quadruple therapy. Moreover, 21% of the hypertensive patients were exposed to polypharmacy. There was a significant relationship (<0.001) between the overall number of chronic medications used per day and the duration of hypertension.
More clinical research is needed to identify the impact of polypharmacy on the quality of healthcare in PHC centres in general and hypertensive patients specifically in different regions of Saudi Arabia.
沙特阿拉伯有许多高血压患者，他们的药物治疗需要密切关注和专业护理。联合用药是患者对抗高血压药物依从性不佳的原因之一。因此，本研究旨在更好地了解沙特阿拉伯麦加市基层医疗（PHC）中心高血压患者的联合用药情况。
这是一项对沙特阿拉伯麦加市10个基层医疗中心随访的高血压患者进行的观察性、横断面描述性研究，研究时间为2019年7月1日至2022年6月30日。使用频率和百分比呈现分类数据，采用Pearson检验测量差异。P值小于0.05被认为具有统计学意义。
本研究共纳入506例患者。患者的平均年龄为60岁，超过一半（69%）为女性。在抗高血压药物使用方面，64%接受抗高血压联合治疗，76%接受双联治疗，21%接受三联治疗，3%接受四联治疗。此外，21%的高血压患者存在联合用药情况。每日使用的慢性药物总数与高血压病程之间存在显著关系（P<0.001）。
需要更多的临床研究来确定联合用药对沙特阿拉伯不同地区基层医疗中心总体医疗质量以及高血压患者医疗质量的影响。
