Sainbhi Amanjyot Singh, Vakitbilir Nuray, Gomez Alwyn, Stein Kevin Y, Froese Logan, Zeiler Frederick A
Department of Biomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB R3T 5V6, Canada.
Section of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3A 1R9, Canada.
Methods Protoc. 2023 Jun 9;6(3):58. doi: 10.3390/mps6030058.
The ability of cerebral vessels to maintain a fairly constant cerebral blood flow is referred to as cerebral autoregulation (CA). Using near-infrared spectroscopy (NIRS) paired with arterial blood pressure (ABP) monitoring, continuous CA can be assessed non-invasively. Recent advances in NIRS technology can help improve the understanding of continuously assessed CA in humans with high spatial and temporal resolutions. We describe a study protocol for creating a new wearable and portable imaging system that derives CA maps of the entire brain with high sampling rates at each point. The first objective is to evaluate the CA mapping system's performance during various perturbations using a block-trial design in 50 healthy volunteers. The second objective is to explore the impact of age and sex on regional disparities in CA using static recording and perturbation testing in 200 healthy volunteers. Using entirely non-invasive NIRS and ABP systems, we hope to prove the feasibility of deriving CA maps of the entire brain with high spatial and temporal resolutions. The development of this imaging system could potentially revolutionize the way we monitor brain physiology in humans since it would allow for an entirely non-invasive continuous assessment of regional differences in CA and improve our understanding of the impact of the aging process on cerebral vessel function.
脑血管维持相当恒定的脑血流量的能力被称为脑自动调节（CA）。使用近红外光谱（NIRS）结合动脉血压（ABP）监测，可以非侵入性地评估连续的CA。NIRS技术的最新进展有助于提高对人类连续评估CA的理解，具有高空间和时间分辨率。我们描述了一种研究方案，用于创建一种新的可穿戴便携式成像系统，该系统可以在每个点以高采样率生成全脑的CA图。第一个目标是在50名健康志愿者中使用分组试验设计评估CA映射系统在各种扰动期间的性能。第二个目标是在200名健康志愿者中使用静态记录和扰动测试来探索年龄和性别对CA区域差异的影响。使用完全非侵入性的NIRS和ABP系统，我们希望证明以高空间和时间分辨率生成全脑CA图的可行性。这种成像系统的开发可能会彻底改变我们监测人类脑生理学的方式，因为它将允许对CA的区域差异进行完全非侵入性的连续评估，并提高我们对衰老过程对脑血管功能影响的理解。
