Racké K, Holzbauer M, Sharman D F
Neurosci Lett. 1986 Jun 30;67(3):324-8. doi: 10.1016/0304-3940(86)90330-7.
The release of endogenous 5-hydroxytryptamine (5-HT) from the in vitro incubated neurointermediate lobe (NIL) of the rat hypophysis was measured by HPLC with electrochemical detection. 5-HT release evoked by electrical stimulation of the pituitary stalk from the NIL, but not from the isolated neural lobe (NL) was enhanced in the presence of the dopamine receptor antagonist sulpiride (1 microM). The opiate receptor antagonist naloxone (1 microM) had no effect on the evoked release of 5-HT from the NIL or NL. In conclusion, the release of endogenous 5-HT from the intermediate lobe is under inhibitory control of endogenous dopamine.
采用高效液相色谱电化学检测法测定大鼠垂体神经中间叶（NIL）体外孵育时内源性5-羟色胺（5-HT）的释放。在多巴胺受体拮抗剂舒必利（1微摩尔）存在的情况下，电刺激垂体柄从NIL而非分离的神经叶（NL）诱发的5-HT释放增强。阿片受体拮抗剂纳洛酮（1微摩尔）对从NIL或NL诱发的5-HT释放没有影响。总之，中间叶内源性5-HT的释放受内源性多巴胺的抑制性控制。
