Oto Julia, Le Quang-Khoi, Schäfer Sebastian D, Kiesel Ludwig, Marí-Alexandre Josep, Gilabert-Estellés Juan, Medina Pilar, Götte Martin
Department of Gynecology and Obstetrics, Münster University Hospital, 48149 Münster, Germany.
Haemostasis, Thrombosis, Arteriosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe, 46026 Valencia, Spain.
Cancers (Basel). 2023 Jun 9;15(12):3125. doi: 10.3390/cancers15123125.
Ovarian cancer (OC) is the eighth cancer both in prevalence and mortality in women and represents the deadliest female reproductive cancer. Due to generally vague symptoms, OC is frequently diagnosed only at a late and advanced stage, resulting in high mortality. The tumor extracellular matrix and cellular matrix receptors play a key role in the pathogenesis of tumor progression. Syndecans are a family of four transmembrane heparan sulfate proteoglycans (PG), including syndecan-1, -2, -3, and -4, which are dysregulated in a myriad of cancers, including OC. Many clinicopathological studies suggest that these proteins are promising diagnostic and prognostic biomarkers for OC. Furthermore, functions of the syndecan family in the regulation of cellular processes make it an interesting pharmacological target for anticancer therapies.
卵巢癌（OC）在女性癌症的发病率和死亡率中均位列第八，是最致命的女性生殖系统癌症。由于症状通常较为模糊，OC往往在晚期才被诊断出来，导致死亡率很高。肿瘤细胞外基质和细胞基质受体在肿瘤进展的发病机制中起着关键作用。Syndecans是一个由四种跨膜硫酸乙酰肝素蛋白聚糖（PG）组成的家族，包括syndecan-1、-2、-3和-4，它们在包括OC在内的多种癌症中表达失调。许多临床病理研究表明，这些蛋白有望成为OC的诊断和预后生物标志物。此外，syndecan家族在细胞过程调节中的功能使其成为抗癌治疗中一个有趣的药理学靶点。
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