School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia.
School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia; Mater Research Institute, Translational Research Institute, The University of Queensland, Brisbane, QLD, Australia.
Biochim Biophys Acta Mol Cell Res. 2023 Oct;1870(7):119532. doi: 10.1016/j.bbamcr.2023.119532. Epub 2023 Jun 29.
Apoptosis is a highly complex and regulated cell death pathway that safeguards the physiological balance between life and death. Over the past decade, the role of Ca signalling in apoptosis and the mechanisms involved have become clearer. The initiation and execution of apoptosis is coordinated by three distinct groups of cysteines proteases: the caspase, calpain and cathepsin families. Beyond its physiological importance, the ability to evade apoptosis is a prominent hallmark of cancer cells. In this review, we will explore the involvement of Ca in the regulation of caspase, calpain and cathepsin activity, and how the actions of these cysteine proteases alter intracellular Ca handling during apoptosis. We will also explore how apoptosis resistance can be achieved in cancer cells through deregulation of cysteine proteases and remodelling of the Ca signalling toolkit.
细胞凋亡是一种高度复杂且受到调控的细胞死亡途径,它维持着生与死之间的生理平衡。在过去的十年中,钙信号在细胞凋亡中的作用及其相关机制变得更加清晰。细胞凋亡的启动和执行受到三种不同的半胱氨酸蛋白酶家族的协调:胱天蛋白酶、钙蛋白酶和组织蛋白酶家族。除了其生理重要性之外,逃避细胞凋亡是癌细胞的一个显著特征。在这篇综述中,我们将探讨钙在调节胱天蛋白酶、钙蛋白酶和组织蛋白酶活性中的作用,以及这些半胱氨酸蛋白酶的作用如何改变细胞凋亡过程中的细胞内钙处理。我们还将探讨如何通过半胱氨酸蛋白酶的失调和钙信号工具包的重塑来实现癌细胞的凋亡抵抗。