新每日持续性头痛的微观结构白质异常：基于 TBSS 分析的 DTI 研究。
Micro-structural white matter abnormalities in new daily persistent headache: a DTI study using TBSS analysis.
机构信息
Headache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, China.
Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, No.119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, China.
出版信息
J Headache Pain. 2023 Jul 2;24(1):80. doi: 10.1186/s10194-023-01620-2.
BACKGROUND
New daily persistent headache (NDPH) is a rare primary headache disorder characterized by daily and persistent sudden onset headaches. The pathogenesis of NDPH remains unclear, and there are few white matter imaging studies related to NDPH. The purpose of this study was to investigate the micro-structural abnormalities of white matter in NDPH and provided insights into the pathogenesis of this disease based on tract-based spatial statistics (TBSS).
METHODS
Twenty-one patients with NDPH and 25 healthy controls (HCs) were included in this study. T1 structural and diffusion magnetic resonance imaging (MRI) were acquired from all participants. Differences in the fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) between patients with NDPH and HCs were investigated using TBSS analysis.
RESULTS
Significantly decreased FA, increased MD and RD were found in patients with NDPH compared to HCs. White matter regions overlaid with decreased FA, increased MD and RD were found in 16 white matter tracts from the Johns Hopkins University ICBM-DTI-81 White-Matter Atlas and Johns Hopkins University White-Matter Tractography Atlas. Specifically, these white matter regions included the right anterior thalamic radiation (ATR), body of the corpus callosum (BCC), bilateral cingulum, left hippocampal cingulum (CGH), left corticospinal tract (CST), forceps major, fornix, left inferior fronto-occipital fasciculus (IFOF), bilateral inferior longitudinal fasciculus (ILF), left posterior limb of the internal capsule (PLIC), right retrolenticular part of the internal capsule (RPIC), splenium of the corpus callosum (SCC), right superior longitudinal fasciculus (SLF) and left uncinate fasciculus (UF). After Bonferroni correction, there were no correlations between the FA, MD, AD and RD values and the clinical characteristics of patients with NDPH (p > 0.05/96).
CONCLUSION
The results of our research indicated that patients with NDPH might have widespread abnormalities in the white matter of the brain.
背景
新发每日持续性头痛（NDPH）是一种罕见的原发性头痛障碍，其特征为每日持续且突发的头痛。NDPH 的发病机制尚不清楚，与 NDPH 相关的脑白质成像研究较少。本研究旨在通过基于束路径的空间统计学（TBSS）探讨 NDPH 患者脑白质的微观结构异常，并为该疾病的发病机制提供见解。
方法
本研究纳入 21 例 NDPH 患者和 25 例健康对照者（HCs）。所有参与者均进行 T1 结构和弥散磁共振成像（MRI）扫描。采用 TBSS 分析比较 NDPH 患者与 HCs 之间各向异性分数（FA）、平均弥散度（MD）、轴向弥散度（AD）和径向弥散度（RD）的差异。
结果
与 HCs 相比，NDPH 患者的 FA 值降低，MD 和 RD 值升高。从约翰霍普金斯大学 ICBM-DTI-81 脑白质图谱和约翰霍普金斯大学脑白质束成像图谱叠加的 FA 值降低、MD 和 RD 值升高的脑白质区域共 16 个。具体而言，这些脑白质区域包括右侧前丘脑辐射（ATR）、胼胝体体部（BCC）、双侧扣带、左侧海马扣带（CGH）、左侧皮质脊髓束（CST）、内囊前肢（forceps major）、穹窿、左侧下额枕束（IFOF）、双侧下纵束（ILF）、左侧内囊后肢（PLIC）、右侧内囊后肢（RPIC）、胼胝体压部（SCC）、右侧上纵束（SLF）和左侧钩束（UF）。经 Bonferroni 校正后，NDPH 患者的 FA、MD、AD 和 RD 值与临床特征之间无相关性（p>0.05/96）。
结论
本研究结果表明，NDPH 患者脑白质可能存在广泛的异常。
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