胎盘生长因子在支气管哮喘和肺纤维化发病机制及进展中的多方面作用：治疗意义

The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis: Therapeutic implications.

作者信息

Huang Dan, Liu Gege, Xu Zhiyi, Chen Shushu, Wang Cuili, Liu Dewei, Cao Jiahao, Cheng Junfen, Wu Bin, Wu Dong

机构信息

Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524000, China.

State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macao SAR 999078, China.

出版信息

Genes Dis. 2022 Nov 14;10(4):1537-1551. doi: 10.1016/j.gendis.2022.10.017. eCollection 2023 Jul.

DOI:10.1016/j.gendis.2022.10.017

PMID:37397552

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10311108/

Abstract

Placental growth factor (PlGF) is a glycosylated dimeric protein that is homologous to vascular endothelial growth factor (VEGF). PlGF expression is upregulated in patients with bronchial asthma, suggesting that it plays a role in the pathogenesis of asthma. Bronchial asthma is characterized by chronic airway inflammation and airway hyperresponsiveness (AHR). After recurrent asthma attacks, pulmonary fibrosis develops and leads to airway remodeling and a further decline in lung function. In this review, we focused on the pivotal role of PlGF in chronic airway inflammation, AHR, and airway remodeling during bronchial asthma. Furthermore, we summarized data showing that PlGF may be a potential therapeutic target in bronchial asthma.

摘要

胎盘生长因子（PlGF）是一种糖基化二聚体蛋白，与血管内皮生长因子（VEGF）同源。支气管哮喘患者的PlGF表达上调，提示其在哮喘发病机制中发挥作用。支气管哮喘的特征为慢性气道炎症和气道高反应性（AHR）。反复哮喘发作后，会发生肺纤维化，导致气道重塑和肺功能进一步下降。在本综述中，我们重点关注了PlGF在支气管哮喘慢性气道炎症、AHR和气道重塑中的关键作用。此外，我们总结了表明PlGF可能是支气管哮喘潜在治疗靶点的数据。