一例甲状旁腺癌合并急性肾衰竭，出现多孔状态、抑郁及严重认知功能减退。

A parathyroid cancer with soporous state, depression, and severe cognitive decline in acute renal failure.

作者信息

Vultaggio Federica, Martino Barbara, Nitro Letizia, Fuccillo Emanuela, Felisati Giovanni, De Pasquale Loredana

机构信息

Otolaryngology Unit, Santi Paolo e Carlo Hospital, Department of Health Sciences Università degli Studi di Milano Milan Italy.

Department of Health Sciences Università degli Studi di Milano Milan Italy.

出版信息

Clin Case Rep. 2023 Jun 29;11(7):e7627. doi: 10.1002/ccr3.7627. eCollection 2023 Jul.

DOI:10.1002/ccr3.7627

PMID:37397577

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10310898/

Abstract

KEY CLINICAL MESSAGE

Soporous state in acute renal failure represent an atypical presentation of parathyroid cancer. Complete prompt investigations and diagnosis have a fundamental role in the management of this disease.

ABSTRACT

This report describes a case of parathyroid carcinoma (PC) with an uncommon first clinical presentation: soporous state, depression, and severe cognitive decline in association with acute renal failure. After discovering extremely high serum calcium and parathyroid hormone (PTH) levels, the diagnosis of primary hyperparathyroidism (pHPT) was made and a surgical en bloc resection was performed. After the surgical intervention, the histological examination revealed the presence of a malignant parathyroid disease, thus confirming our first preoperative suspicion.

摘要

关键临床信息

急性肾衰竭中的昏睡状态是甲状旁腺癌的一种非典型表现。迅速完成全面检查和诊断对该疾病的治疗至关重要。

摘要

本报告描述了一例甲状旁腺癌（PC），其首次临床表现罕见：昏睡状态、抑郁以及与急性肾衰竭相关的严重认知功能减退。在发现血清钙和甲状旁腺激素（PTH）水平极高后，诊断为原发性甲状旁腺功能亢进症（pHPT）并进行了整块手术切除。手术干预后，组织学检查显示存在恶性甲状旁腺疾病，从而证实了我们术前的初步怀疑。