胶原蛋白结构和信号转导协调癌症的发展。
Collagen architecture and signaling orchestrate cancer development.
机构信息
Institutes of Biomedical Sciences, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA.
出版信息
Trends Cancer. 2023 Sep;9(9):764-773. doi: 10.1016/j.trecan.2023.06.002. Epub 2023 Jul 1.
The tumor microenvironment (TME) controls tumor progression and maintenance. Accordingly, tumor-centric cancer treatment must adjust to being more holistic and TME-centric. Collagens are the most abundant TME proteins, and their dynamic remodeling profoundly affects both TME architecture and tumor development. Recent evidence shows that in addition to being structural elements, collagens are an important source of nutrients and decisive growth controlling and immunoregulatory signals. This review focuses on macropinocytosis-dependent collagen support of cancer cell metabolism and the role of collagen fiber remodeling and trimer heterogeneity in control of tumor bioenergetics, growth, progression, and response to therapy. If properly translated, these basic advances may alter the future of cancer treatment.
肿瘤微环境 (TME) 控制着肿瘤的发生和维持。因此，以肿瘤为中心的癌症治疗必须更加全面，以 TME 为中心。胶原是 TME 中最丰富的蛋白质，其动态重塑深刻影响着 TME 结构和肿瘤的发展。最近的证据表明，胶原除了作为结构元件外，还是营养物质的重要来源，也是决定肿瘤生长和免疫调节信号的关键因素。这篇综述重点介绍了依赖巨胞饮作用的胶原对癌细胞代谢的支持作用，以及胶原纤维重塑和三聚体异质性在控制肿瘤生物能量、生长、进展和对治疗的反应中的作用。如果这些基础进展能够得到正确的转化，它们可能会改变癌症治疗的未来。
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