土耳其西部男性 HIV 感染者勃起功能障碍的患病率及相关因素：一项横断面研究。

Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences, Tepecik Training and Research Hospital, Izmir, Turkey.

Department of Infectious Diseases and Clinical Microbiology, Ankara City Hospital, Ankara, Turkey.

Int J STD AIDS. 2023 Nov;34(13):914-920. doi: 10.1177/09564624231173029. Epub 2023 Jul 4.

BACKGROUND

The majority of people living with HIV in our country are younger men. However, limited data exist for the sexual health of these patients. Knowledge of the epidemiology in this population may improve health outcomes across the continuum of HIV care. The aim of this study was to determine the prevalence of erectile dysfunction (ED) and its association with some clinical and laboratory factors.

METHODS

A cross-sectional study was conducted using random sampling in men living with HIV (MLWH) at a tertiary hospital in Turkey. Patients were asked to fill out the five-item International Index of Erectile Function (IIEF-5), and blood was collected for HIV viral load, CD4 T lymphocyte count, lipids and hormone levels to assess biological aspects at the same clinical visit.

RESULTS

A total of 107 MLWH were recruited. Mean age was 40.4 ± 12.4 years. ED was found in 73.8% ( = 79) of the participants. Severe ED was found in 6.3%, moderate in 5.1%, mild-moderate 35.4%, mild 53.2% of the participants, respectively. The mean age of men with erectile dysfunction was 42.5 ± 12.5 years, while those without erectile dysfunction were 34.5 ± 10 years (p:0.00). ED was detected more frequently in cases with high Low Density Lipoprotein (LDL) levels (p:0.003). There was no statistically significant difference between ED presence and having hormone abnormality. There was a moderate, negative correlation between age and ED score (r: -0.440, < 0.001). A negative and low correlation was found between triglyceride level and ED score (r: -0.233, p:0.02). The only predictive variable was age in the multivariate analysis [B: -0.155 (95% CI -0.232 to -0.078), : <0.001].

CONCLUSIONS

Our study revealed a high prevalence of ED in the MLWH cohort. Age was found to be the only factor associated with ED. HIV clinicians should consider routine ED screening with validated measures as a part of the follow-up scheme to improve integrated wellbeing in MLWH.

背景

我国大多数 HIV 感染者为年轻男性。然而，针对此类患者的性健康状况，目前仅有少量数据。了解该人群的流行病学情况可能会改善整个 HIV 护理连续体的健康结局。本研究旨在确定勃起功能障碍（ED）的流行率及其与某些临床和实验室因素的关系。

方法

本研究采用土耳其一家三级医院的 HIV 感染者（MLWH）的随机抽样进行横断面研究。在同一就诊时，要求患者填写 5 项国际勃起功能指数（IIEF-5），并采集血液进行 HIV 病毒载量、CD4 T 淋巴细胞计数、血脂和激素水平检测，以评估生物学指标。

结果

共纳入 107 名 MLWH。平均年龄为 40.4 ± 12.4 岁。73.8%（79 例）的参与者存在 ED。严重 ED 占 6.3%，中度 ED 占 5.1%，轻度中度 ED 占 35.4%，轻度 ED 占 53.2%。有 ED 的男性平均年龄为 42.5 ± 12.5 岁，无 ED 的男性平均年龄为 34.5 ± 10 岁（p：0.00）。存在 ED 的患者中，低水平的低密度脂蛋白（LDL）更为常见（p：0.003）。ED 与激素异常之间无统计学显著差异。ED 与年龄之间存在中度负相关（r：-0.440，<0.001）。ED 评分与甘油三酯水平之间存在低度负相关（r：-0.233，p：0.02）。多元分析中唯一的预测变量是年龄[B：-0.155（95%CI -0.232 至 -0.078），p：<0.001]。