Xia Shuangbo, Du Yushan, Ren Ziyang, Zhang Jinjuan, Gao Suhong, Wang Jiamei, Li Zhiwen, Liu Xiaohong, Liu Jufen
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Institute of Reproductive and Child Health / National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China.
China CDC Wkly. 2023 Jun 9;5(23):505-510. doi: 10.46234/ccdcw2023.095.
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: Inconsistent results have been reported on the association between periconceptional folic acid only (FAO) or multiple micronutrients containing folic acid (MMFA) supplementation and the risk of gestational diabetes mellitus (GDM) in previous research.
WHAT IS ADDED BY THIS REPORT?: In a prospective cohort study conducted among pregnant women in Haidian District, Beijing Municipality, it was observed that those who took MMFA demonstrated a higher likelihood of developing GDM in comparison to those who consumed FAO periconceptionally. Interestingly, the increased risk for GDM in pregnant women supplemented with MMFA compared to FAO was primarily due to changes in fasting plasma glucose.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: It is highly recommended that women prioritize the use of FAO in order to yield potential benefits in the prevention of GDM.
先前的研究报告了孕前仅补充叶酸（FAO）或含叶酸的多种微量营养素（MMFA）与妊娠期糖尿病（GDM）风险之间的关联结果并不一致。
在北京市海淀区对孕妇进行的一项前瞻性队列研究中，观察到与孕前摄入FAO的孕妇相比，服用MMFA的孕妇患GDM的可能性更高。有趣的是，与FAO相比，补充MMFA的孕妇患GDM风险增加主要是由于空腹血糖的变化。
强烈建议女性优先使用FAO，以便在预防GDM方面产生潜在益处。
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