MS Center Amsterdam, Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Nutr Neurosci. 2024 May;27(5):499-505. doi: 10.1080/1028415X.2023.2225271. Epub 2023 Jul 6.
The relationship between being overweight during early life and disease course in multiple sclerosis (MS) is unresolved. We investigated the association between being overweight or obese during early life (childhood and adolescence) and MS case status, age of first symptom onset and onset type in people with MS (pwMS) of the same birth year.
We enrolled 363 PwMS and 125 healthy controls (HC) from Project Y, a Dutch population-based cross-sectional cohort study including all PwMS born in 1966 and age and sex-matched HC. The associations between weight during childhood and adolescence (non-overweight vs. overweight or obese) and MS, age at symptom onset and onset type (relapsing vs. progressive) were assessed using logistic and linear regressions. In addition, sex-separated associations were explored.
Being overweight or obese during childhood (OR = 2.82, 95% CI 1.17-6.80) and adolescence (OR = 2.45, 95% CI 1.13-5.34) was associated with developing MS. Furthermore, being overweight or obese during adolescence was associated with a younger age of onset ( = -0.11, = 0.041). Of all 47 patients with a primary progressive (PP) onset type, only one patient (2.1%) was overweight or obese during childhood, whereas 45 patients with a relapsing remitting (RR) onset (14.3%) were overweight or obese during childhood (PP vs. RR = 0.017; PP vs. HC = 0.676; RR vs. HC, = 0.015). However, using logistic regression analysis we did not find evidence of a significant association.
In a nationwide population-based birth year cohort, being overweight or obese during childhood or adolescence is associated with MS prevalence and an earlier age of onset, but does not seem to associate with the type of onset.
生命早期超重与多发性硬化症（MS）病程之间的关系尚未明确。我们研究了生命早期（儿童期和青春期）超重或肥胖与 MS 患者（pwMS）发病状况、首发症状年龄和发病类型之间的关系，这些患者均来自同一出生年份的荷兰基于人群的横断面队列研究项目 Y。
我们纳入了来自项目 Y 的 363 名 pwMS 和 125 名健康对照者（HC）。项目 Y 是一项荷兰基于人群的横断面队列研究，纳入了所有 1966 年出生的 pwMS 及年龄和性别匹配的 HC。采用逻辑回归和线性回归分析儿童期和青春期体重（非超重与超重或肥胖）与 MS、首发症状年龄和发病类型（复发缓解型 vs. 进展型）之间的相关性。此外，还探索了性别分层的相关性。
儿童期（OR=2.82，95%CI 1.17-6.80）和青春期（OR=2.45，95%CI 1.13-5.34）超重或肥胖与 MS 的发生相关。此外，青春期超重或肥胖与发病年龄较小相关（β=-0.11，P=0.041）。在所有 47 名首发为原发性进展型（PP）的患者中，仅有 1 名（2.1%）儿童期超重或肥胖，而 45 名首发为复发缓解型（RR）的患者（14.3%）儿童期超重或肥胖（PP 与 RR：P=0.017；PP 与 HC：P=0.676；RR 与 HC：P=0.015）。然而，采用逻辑回归分析，我们未发现有统计学意义的相关性。
在全国性基于人群的出生年份队列中，儿童期或青春期超重或肥胖与 MS 患病率和发病年龄较早相关，但似乎与发病类型无关。
