Rodríguez-Duque María Soledad, Martín Soler Paula, González Vela M Carmen, Gómez Román Jose Javier
Servicio de Anatomía Patológica, Hospital Universitario Marqués de Valdecilla, Santander, España.
Servicio de Anatomía Patológica, Hospital Universitario Marqués de Valdecilla, Santander, España.
Rev Esp Patol. 2023 Jul-Sep;56(3):186-190. doi: 10.1016/j.patol.2021.07.001. Epub 2021 Oct 1.
We present a case of a 64-year-old male with a history of Crohn's disease who presented with an episode of acute abdominal pain. He was being investigated for a dermatological lesion. A skin and lung biopsy both revealed histiocytosis of the "L" (Langerhans) group. The skin biopsy showed a proliferation of histiocytic cells expressing Langerin, CD1a and S100 and the molecular study was positive for the BRAF p.V600E mutation. In the lung biopsy, a proliferation of histiocytic cells was found, which were positive for CD68 and S100 and negative for Langerin and CD1a; mutations in NRAS c.38G>A in exon 2 (p.G13D) were also detected.
我们报告一例64岁男性，有克罗恩病病史，因急性腹痛发作前来就诊。他正在接受皮肤病损的检查。皮肤和肺部活检均显示为“L”（朗格汉斯）组组织细胞增多症。皮肤活检显示表达朗格素、CD1a和S100的组织细胞增生，分子研究显示BRAF p.V600E突变呈阳性。肺部活检发现组织细胞增生，CD68和S100呈阳性，朗格素和CD1a呈阴性；还检测到NRAS基因外显子2中c.38G>A（p.G13D）的突变。
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