Deacon Rachel M, Mills Llewellyn, Bruno Raimondo, Mammen Kristie, Dunlop Adrian, Childs Steven, Shakeshaft Anthony, Holmes Jennifer, Lintzeris Nicholas
Sydney School of Medicine (Central Clinical School), Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Drug and Alcohol Services, South Eastern Sydney Local Health District, Sydney, NSW, Australia.
Addiction. 2023 Dec;118(12):2457-2465. doi: 10.1111/add.16295. Epub 2023 Jul 8.
The Austraian Treatment Outcomes Profile (ATOP) is a brief clinical outcomes tool used widely in the Australian alcohol and other drugs treatment sector to monitor clients' substance use, health, wellbeing and clinical risk factors. It has demonstrated reliability and validity, and has recommended clinical cut-offs for assessing single-occasion client-rated health scores. This study determined clinically meaningful change thresholds for ATOP substance use and health and wellbeing variables for use by clinicians in monitoring client progress, and for quality improvement and service evaluation.
DESIGN, SETTING AND PARTICIPANTS: A framework for assessing clinically meaningful changes scores was developed by (1) calculating statistically reliable change thresholds using data-driven techniques with a reference sample of clinical ATOP data and (2) conducting a multi-disciplinary subject matter expert group to review the utility and validity of data-derived clinically meaningful change. The study was conducted within Outpatient Alcohol and Other Drug treatment services in New South Wales, Australia. The reference sample comprised 6100 ATOPs from clients at entry to public outpatient Alcohol and Other Drug treatment services; the subject matter expert group comprised 29 key stakeholders from the specialist alcohol and other drug treatment sector.
We used the Reliable Change Index method to calculate clinically meaningful change thresholds for ATOP variables. For substance use variables, a change of 30% in days of use in the last 28 (minimum 4 days) was the threshold for clinically meaningful change for substance use; for health and wellbeing variables, a change of 2 or more points in psychological health, physical health or quality of life scores (measured on 0-10 scales) was the minimum clinically meaningful change.
Clinically meaningful change thresholds have been proposed for Australian Treatment Outcomes Profile substance use and health and wellbeing items, based on statistical reliability and subject matter expert assessment. These will be used in the development of an outcomes metric for assessing change and assigning meaning in aggregated data for evaluation of services.
澳大利亚治疗结果概况(ATOP)是一种简短的临床结果工具,在澳大利亚酒精及其他药物治疗领域被广泛用于监测客户的物质使用情况、健康状况、幸福感和临床风险因素。它已证明具有可靠性和有效性,并推荐了用于评估单次客户自评健康评分的临床临界值。本研究确定了ATOP物质使用、健康和幸福感变量具有临床意义的变化阈值,供临床医生用于监测客户进展,以及进行质量改进和服务评估。
设计、设置和参与者:通过以下方式制定了评估具有临床意义变化分数的框架:(1)使用数据驱动技术,基于临床ATOP数据的参考样本计算统计可靠的变化阈值;(2)组建一个多学科主题专家小组,以审查数据得出的具有临床意义变化的实用性和有效性。该研究在澳大利亚新南威尔士州的门诊酒精及其他药物治疗服务机构内进行。参考样本包括6100份来自进入公共门诊酒精及其他药物治疗服务机构的客户的ATOP;主题专家小组由来自酒精及其他药物治疗专业领域的29名关键利益相关者组成。
我们使用可靠变化指数方法来计算ATOP变量具有临床意义的变化阈值。对于物质使用变量,过去28天(至少4天)使用天数变化30%是物质使用具有临床意义变化的阈值;对于健康和幸福感变量,心理健康、身体健康或生活质量评分(0至10分制)变化2分或更多是最小的具有临床意义的变化。
基于统计可靠性和主题专家评估,已为澳大利亚治疗结果概况的物质使用、健康和幸福感项目提出了具有临床意义的变化阈值。这些阈值将用于制定一个结果指标,以评估变化并为服务评估的汇总数据赋予意义。