腮腺侵犯在外耳道腺样囊性癌中的作用。

The Role of Parotid Gland Invasion in Adenoid Cystic Carcinoma of the External Auditory Canal.

机构信息

Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai, China.

Key Laboratory of Hearing Medicine, Ministry of Health, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai, China.

出版信息

Laryngoscope. 2024 Jan;134(1):419-425. doi: 10.1002/lary.30855. Epub 2023 Jul 8.

DOI:10.1002/lary.30855

PMID:37421252

Abstract

OBJECTIVE

This study aimed to investigate the significance of parotid gland invasion in predicting distant metastasis of adenoid cystic carcinoma in the external auditory canal.

STUDY DESIGN

Single-institution retrospective cohort study.

METHODS

A retrospective review of patients with adenoid cystic carcinoma of the external auditory canal who underwent surgery was performed. Information on patient demographics, parotid gland invasion, tumor stage, perineural invasion, lymphovascular invasion, and follow-up data were collected and analyzed.

RESULTS

One hundred twenty-nine patients were identified for review. Parotid gland invasion was noted in 45 patients (34.9%). Parotid gland invasion was significantly associated with tumor stage, perineural invasion, distant metastasis, and postoperative adjuvant therapy. Distant metastasis was noted in 30 patients (23.3%). Multivariate Cox proportional hazards analysis identified parotid gland invasion as an independent risk factor for predicting distant metastasis. The 5-year distant metastasis-free survival rate was 83.6% for patients without parotid gland invasion and 61.8% for patients with parotid gland invasion (p = 0.010).

CONCLUSIONS

The parotid gland invasion rate is relatively high in adenoid cystic carcinoma of the external auditory canal and is significantly related to tumor stage. Parotid gland invasion is associated with worse distant metastasis-free survival.

LEVEL OF EVIDENCE

4 Laryngoscope, 134:419-425, 2024.

摘要

目的

本研究旨在探讨腮腺侵犯对外耳道腺样囊性癌远处转移的预测意义。

研究设计

单机构回顾性队列研究。

方法

对接受手术治疗的外耳道腺样囊性癌患者进行回顾性研究。收集并分析患者人口统计学资料、腮腺侵犯、肿瘤分期、神经周围侵犯、脉管侵犯和随访数据。

结果

共纳入 129 例患者进行回顾。45 例（34.9%）患者存在腮腺侵犯。腮腺侵犯与肿瘤分期、神经周围侵犯、远处转移和术后辅助治疗显著相关。30 例（23.3%）患者发生远处转移。多因素 Cox 比例风险分析显示，腮腺侵犯是预测远处转移的独立危险因素。无腮腺侵犯患者的 5 年无远处转移生存率为 83.6%，有腮腺侵犯患者的 5 年无远处转移生存率为 61.8%（p=0.010）。