Park D H, Snyder D W, Joh T H
Brain Res. 1986 Jul 16;378(1):183-5. doi: 10.1016/0006-8993(86)90303-3.
Tryptophan hydroxylase (TPH) is the rate limiting enzyme in serotonin biosynthesis, so its development is very important to the functional maturation of the serotonergic neurons. In the present study, we examined changes of TPH activity in serotonergic cell bodies and terminals of rat brain during postnatal development. TPH activity reached its peak in the cell body regions at 24 days after birth, while the enzyme activity in a terminal region rose to its plateau at day 30. TPH activity in adult rat is the highest in nucleus raphe dorsalis, then nucleus raphe centralis and hypothalamus in a decreasing order.
色氨酸羟化酶（TPH）是5-羟色胺生物合成中的限速酶，因此其发育对5-羟色胺能神经元的功能成熟非常重要。在本研究中，我们检测了出生后发育过程中大鼠脑内5-羟色胺能细胞体和终末中TPH活性的变化。TPH活性在出生后24天时在细胞体区域达到峰值，而终末区域的酶活性在第30天时升至平稳状态。成年大鼠中TPH活性在中缝背核最高，其次是中缝中央核和下丘脑，活性依次递减。
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