代谢性脑 MRI、淀粉样蛋白 PET 与临床因素的关联：来自开放获取成像研究数据集的阿尔茨海默病与正常对照研究。

The Association of Metabolic Brain MRI, Amyloid PET, and Clinical Factors: A Study of Alzheimer's Disease and Normal Controls From the Open Access Series of Imaging Studies Dataset.

机构信息

Department of Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.

Smart Life Science Lab, Center for Health Science Innovation, Osaka Metropolitan University, Osaka, Japan.

出版信息

J Magn Reson Imaging. 2024 Apr;59(4):1341-1348. doi: 10.1002/jmri.28892. Epub 2023 Jul 9.

DOI:10.1002/jmri.28892

PMID:37424114

Abstract

BACKGROUND

Although brain activities in Alzheimer's disease (AD) might be evaluated MRI and PET, the relationships between brain temperature (BT), the index of diffusivity along the perivascular space (ALPS index), and amyloid deposition in the cerebral cortex are still unclear.

PURPOSE

To investigate the relationship between metabolic imaging measurements and clinical information in patients with AD and normal controls (NCs).

STUDY TYPE

Retrospective analysis of a prospective dataset.

POPULATION

58 participants (78.3 ± 6.8 years; 30 female): 29 AD patients and 29 age- and sex-matched NCs from the Open Access Series of Imaging Studies dataset.

FIELD STRENGTH/SEQUENCE: 3T; T1-weighted magnetization-prepared rapid gradient-echo, diffusion tensor imaging with 64 directions, and dynamic F-florbetapir PET.

ASSESSMENT

Imaging metrics were compared between AD and NCs. These included BT calculated by the diffusivity of the lateral ventricles, ALPS index that reflects the glymphatic system, the mean standardized uptake value ratio (SUVR) of amyloid PET in the cerebral cortex and clinical information, such as age, sex, and MMSE.

STATISTICAL TESTS

Pearson's or Spearman's correlation and multiple linear regression analyses. P values <0.05 were defined as statistically significant.

RESULTS

Significant positive correlations were found between BT and ALPS index (r = 0.44 for NCs), while significant negative correlations were found between age and ALPS index (r = -0.43 for AD and - 0.47 for NCs). The SUVR of amyloid PET was not significantly associated with BT (P = 0.81 for AD and 0.21 for NCs) or ALPS index (P = 0.10 for AD and 0.52 for NCs). In the multiple regression analysis, age was significantly associated with BT, while age, sex, and presence of AD were significantly associated with the ALPS index.

DATA CONCLUSION

Impairment of the glymphatic system measured using MRI was associated with lower BT and aging.

LEVEL OF EVIDENCE

3 TECHNICAL EFFICACY STAGE: 1.

摘要

背景

虽然大脑活动可以通过 MRI 和 PET 进行评估，但脑温（BT）、血管周围空间沿扩散指数（ALPS 指数）与大脑皮质淀粉样蛋白沉积之间的关系仍不清楚。

目的

探讨代谢成像测量值与 AD 患者和正常对照（NC）临床信息之间的关系。

研究类型

前瞻性数据集的回顾性分析。

人群

58 名参与者（78.3±6.8 岁；30 名女性）：29 名 AD 患者和 29 名年龄和性别匹配的来自 Open Access Series of Imaging Studies 数据集的 NC。

磁场强度/序列：3T；T1 加权磁化准备快速梯度回波、扩散张量成像（64 个方向）和动态 F-氟比他滨 PET。

评估

比较 AD 和 NC 之间的成像指标。这些指标包括由侧脑室扩散计算得出的 BT、反映脑淋巴系统的 ALPS 指数、大脑皮质淀粉样蛋白 PET 的平均标准化摄取值比（SUVR）以及年龄、性别和 MMSE 等临床信息。

统计检验

Pearson 或 Spearman 相关和多元线性回归分析。P 值<0.05 被定义为统计学显著。

结果

NC 中 BT 与 ALPS 指数呈显著正相关（r=0.44），而 AD 和 NC 中年龄与 ALPS 指数呈显著负相关（r=-0.43 和-0.47）。AD 患者的 SUVR 与 BT（P=0.81）或 ALPS 指数（P=0.10）无显著相关性，NC 患者的 SUVR 与 BT（P=0.21）或 ALPS 指数（P=0.52）无显著相关性。多元回归分析表明，年龄与 BT 显著相关，而年龄、性别和 AD 的存在与 ALPS 指数显著相关。