Ikeda H, Odaka T
Int J Cancer. 1979 Apr 15;23(4):514-8. doi: 10.1002/ijc.2910230412.
G mice carrying the Fv-4r resistant allele supported virus growth neither at an early nor a later (Kai et al., 1976) stage of infection with NB-tropic FLV. This resistance could not be abolished by treatment of G mice with cyclophosphamide or cortisone acetate. By bone-marrow or spleen-cell transplantation into irradiated mice, the resistan-e of G mice could be transferred to Fv-4-susceptible mice. Conversely, transfer of bone-marrow or spleen cells of Fv-4-susceptible mice rendered G mice susceptible. It could be concluded that, as assessed by the virus content in the spleen, helper LLV grows mainly in radiosensitive, bone-marrow-derived cells, and the Fv-4 gene is expressed in these cells.
携带Fv-4r抗性等位基因的G小鼠在感染嗜NB性FLV的早期和晚期（Kai等人，1976年）均不支持病毒生长。用环磷酰胺或醋酸可的松处理G小鼠并不能消除这种抗性。通过将骨髓或脾细胞移植到受辐照的小鼠中，G小鼠的抗性可以转移到对Fv-4敏感的小鼠中。相反，将对Fv-4敏感的小鼠的骨髓或脾细胞进行移植会使G小鼠变得敏感。可以得出结论，以脾脏中的病毒含量评估，辅助性LLV主要在对辐射敏感的骨髓来源细胞中生长，并且Fv-4基因在这些细胞中表达。
