Faulkner Justin D, Carballo Christopher J, Acquista Elizabeth, Baughman Samuel D, Powers William F, Novosel Timothy J, Yon James R
Department of General Surgery & Surgical Critical Care, New Hanover Regional Medical Center, Wilmington, NC, USA.
Am Surg. 2023 Sep;89(9):3968-3970. doi: 10.1177/00031348221086815. Epub 2023 Jul 11.
The Gaboon viper () is an exotic snake native to sub-Saharan Africa. Gaboon viper venom is an extremely toxic hemotoxin, causing severe coagulopathy and local tissue necrosis. These are not aggressive snakes and therefore bites involving humans are rare and there is not a substantial amount of literature documenting how to manage these injuries and resultant coagulopathies. We report a 29-year-old male presenting 3 hours after a Gaboon viper envenomation resulting in coagulopathy requiring massive resuscitation and multiple doses of antivenom. The patient received various blood products based on thromboelastography (TEG) and also underwent early continuous renal replacement therapy (CRRT) to assist in correction of severe acidosis and acute renal failure. The combination of TEG to guide resuscitation, administration of antivenom, and early implementation of CRRT allowed our team to correct venom-induced consumptive coagulopathy and ultimately allow the patient to survive following this extremely deadly Gaboon viper envenomation.
加蓬咝蝰是一种原产于撒哈拉以南非洲的外来蛇类。加蓬咝蝰毒液是一种剧毒的血液毒素,会导致严重的凝血病和局部组织坏死。这些蛇并不具有攻击性,因此涉及人类的咬伤很少见,也没有大量文献记录如何处理这些损伤及由此引发的凝血病。我们报告了一名29岁男性,在被加蓬咝蝰咬伤3小时后出现凝血病,需要大量复苏治疗并多次注射抗蛇毒血清。患者根据血栓弹力图(TEG)接受了各种血液制品治疗,还接受了早期连续性肾脏替代疗法(CRRT),以协助纠正严重酸中毒和急性肾衰竭。TEG指导复苏、抗蛇毒血清的使用以及CRRT的早期实施相结合,使我们的团队能够纠正毒液引起的消耗性凝血病,并最终使患者在这次极其致命的加蓬咝蝰咬伤后存活下来。