胎儿 60 周龄后患眼内注药治疗后视网膜血管发育进展的定量评估

Quantitative Evaluation of Progression of Retinal Vascularization After 60 Weeks Postmenstrual Age in Infants Treated With Bevacizumab.

出版信息

Ophthalmic Surg Lasers Imaging Retina. 2023 Jul;54(7):417-424. doi: 10.3928/23258160-20230626-01. Epub 2023 Jun 1.

DOI:10.3928/23258160-20230626-01

PMID:37432070

Abstract

BACKGROUND AND OBJECTIVE

To investigate the progression of retinal vascularization after 60 weeks postmenstrual age (PMA) in eyes treated with intravitreal bevacizumab (IVB).

PATIENTS AND METHODS

Twenty-seven eyes that were treated with IVB and underwent two consecutive fluorescein angiographies (FA) after 60 weeks PMA. Horizontal disc diameter (DD), disc-to-fovea (DF) distance, and length of temporal retinal vascularization (LTRV) were measured in pixels on the two consecutive angiograms.

RESULTS

Mean age at first and final FA sessions were 77.7 ± 15.7 and 168.0 ± 49.0 weeks PMA, respectively. The DF/DD ratio was 3.30 ± 0.46 and 3.16 ± 0.46 in the first and final FAs ( = 0.001), respectively. The LTRV/DD ratio was 13.38 ± 2.12 and 13.15 ± 2.13 in the first and final FAs ( = 0.027), respectively. The LTRV/DF ratio was 4.06 ± 0.39 and 4.17 ± 0.42, respectively ( = 0.032).

CONCLUSION

Temporal retinal vascularization did not progress despite an average follow-up of 90 weeks in pixel units and DD. .

摘要

背景与目的

研究在 60 周龄（PMA）后接受玻璃体腔内贝伐单抗（IVB）治疗的眼睛中视网膜血管化的进展情况。

患者与方法

27 只眼接受 IVB 治疗，并在 60 周 PMA 后进行了两次连续的荧光素血管造影（FA）。在两次连续的血管造影上以像素为单位测量水平视盘直径（DD）、视盘至黄斑（DF）距离和颞侧视网膜血管化长度（LTRV）。

结果

首次和最后一次 FA 检查的平均年龄分别为 77.7 ± 15.7 和 168.0 ± 49.0 周 PMA。首次和最后一次 FA 的 DF/DD 比值分别为 3.30 ± 0.46 和 3.16 ± 0.46（ = 0.001）。首次和最后一次 FA 的 LTRV/DD 比值分别为 13.38 ± 2.12 和 13.15 ± 2.13（ = 0.027）。首次和最后一次 FA 的 LTRV/DF 比值分别为 4.06 ± 0.39 和 4.17 ± 0.42（ = 0.032）。