Do Xuan-Hai, Tong Thanh-Hai, Nguyen Trung-Chuc, Ngo Tuan-Anh, Tran Minh-Trang Thi
Department of Practical and Experimental Surgery, Vietnam Military Medical University, Hanoi, Vietnam.
Plastic Surgery Center, National Burn Hospital, Vietnam Military Medical University, Hanoi, Vietnam.
Korean J Transplant. 2023 Jun 30;37(2):109-117. doi: 10.4285/kjt.23.0019. Epub 2023 May 25.
In Vietnam, the rate of absolute uterine factor infertility is increasing, but no study has been published on uterine transplantation. The present study was designed to comprehensively observe the canine uterine anatomy and to examine the possibility of using a living canine donor for uterine transplantation training and further research.
Ten female Vietnamese mixed-breed dogs were sacrificed for anatomical research, and 15 additional pairs were used to evaluate the novel uterine transplant model.
The anatomic features of the canine uterus differed considerably from those of the human uterus, with the uterine vessels originating from branches of the pudendal vessels (also known as the vaginal vessels). The uterine vascular pedicle had a small diameter (1 to 1.5 mm for arteries and 1.2 to 2.0 mm for veins) and required manipulation under a microscope. To perform uterine transplantation, the donor specimen's artery and vein lengths were successfully reconstructed by anastomosis between both sides of the vasculature using autologous Y-shaped subcutaneous veins. The living-donor uterine transplantation model constructed in this study was feasible, with the transplanted uterus surviving in 86.7% of cases (13/15).
Uterine transplantation was successfully performed in a Vietnamese canine living donor model. This model could be helpful in uterine transplantation training and improve the transplantation success rate in humans.
在越南，绝对子宫因素不孕症的发生率正在上升，但尚未有关于子宫移植的研究发表。本研究旨在全面观察犬类子宫解剖结构，并探讨使用活体犬类供体进行子宫移植培训及进一步研究的可能性。
处死10只越南雌性杂种犬用于解剖学研究，另外使用15对犬进行新型子宫移植模型评估。
犬类子宫的解剖特征与人类子宫有很大差异，子宫血管起源于阴部血管（也称为阴道血管）的分支。子宫血管蒂直径较小（动脉为1至1.5毫米，静脉为1.2至2.0毫米），需要在显微镜下操作。为进行子宫移植，通过使用自体Y形皮下静脉对血管两侧进行吻合，成功重建了供体标本的动脉和静脉长度。本研究构建的活体供体子宫移植模型是可行的，移植子宫在86.7%的病例（13/15）中存活。
在越南犬类活体供体模型中成功进行了子宫移植。该模型可能有助于子宫移植培训并提高人类移植成功率。
