Witten B I
Fertil Steril. 1986 Sep;46(3):397-401. doi: 10.1016/s0015-0282(16)49575-0.
Twenty-five hyperprolactinemic patients were given the diagnosis of associated luteal phase defect (LPD) on the basis of endometrial biopsy. Fifteen patients were found to have glandular stromal synchrony, and 10 had glandular stromal asynchrony (GSA). After 3 months of initial bromocriptine therapy, the patients were divided into two groups and treated separately on the basis of the endometrial histologic pattern found. Persistent GSA was complemented with clomiphene citrate. The raw pregnancy rates were identical for both groups. Progesterone values between the two groups were not significantly different. Life-table analysis projected the cumulative pregnancy rate on the basis of the protocol of therapy administered. The efficacy of utilizing a combined drug approach based on the endometrial biopsy seems prudent in managing the fertility rate of the hyperprolactenemic patient with LPD.
根据子宫内膜活检结果，25名高催乳素血症患者被诊断为伴有黄体期缺陷（LPD）。其中15名患者存在腺间质同步，10名存在腺间质不同步（GSA）。在最初使用溴隐亭治疗3个月后，根据所发现的子宫内膜组织学模式将患者分为两组并分别进行治疗。持续性GSA患者加用枸橼酸氯米芬。两组的原始妊娠率相同。两组之间的孕酮值无显著差异。生命表分析根据所给予的治疗方案预测累积妊娠率。基于子宫内膜活检采用联合药物治疗方法来管理高催乳素血症合并LPD患者的生育率似乎是合理的。
