Harrison R M, Lewis R W, Roberts J A
Fertil Steril. 1986 Sep;46(3):500-10.
Varicocele was surgically induced in monkeys to study the long-term effects of the condition on seminal and testicular parameters. Sperm motility was depressed but improved after varicocelectomy. Sperm concentration was less affected, but sperm morphology showed long-term degenerative changes, i.e., for more than 2 years. Testicular blood flow was depressed acutely but returned to normal after 2 years. Electron microscopy showed changes in the basal lamina and spermatogonia that persisted throughout the study. Left adrenalectomy, at the time of varicocele induction, did not alter the development of varicocele-related changes. The sequence of changes suggests that the effects of this experimental varicocele may be reversed in the monkey model through changes in collateral and ancillary revascularization.
在猴子身上通过手术诱导精索静脉曲张，以研究该病症对精液和睾丸参数的长期影响。精索静脉曲张手术后精子活力降低但有所改善。精子浓度受影响较小，但精子形态出现了长期的退行性变化，即超过两年。睾丸血流量急性降低，但两年后恢复正常。电子显微镜显示，在整个研究过程中，基膜和精原细胞都有变化。在诱导精索静脉曲张时进行左肾上腺切除术，并未改变与精索静脉曲张相关变化的发展。这些变化的顺序表明，在猴子模型中，这种实验性精索静脉曲张的影响可能通过侧支和辅助血管重建的变化而逆转。
