Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Andrology Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Stem Cell Rev Rep. 2023 Oct;19(7):2073-2093. doi: 10.1007/s12015-023-10577-3. Epub 2023 Jul 13.
Infertility has become one of the most common issues worldwide, which has negatively affected society and infertile couples. Meanwhile, male infertility is responsible for about 50% of infertility. Accordingly, a great number of researchers have focused on its treatment during the last few years; however, current therapies such as assisted reproductive technology (ART) are not effective enough in treating male infertility. Because of their self-renewal and differentiation capabilities and unlimited sources, stem cells have recently raised great hope in the treatment of reproductive system disorders. Stem cells are undifferentiated cells that can induce different numbers of specific cells, such as male and female gametes, demonstrating their potential application in the treatment of infertility. The present review aimed at identifying the causes and potential factors that influence male fertility. Besides, we highlighted the recent studies that investigated the efficiency of stem cells such as spermatogonial stem cells (SSCs), embryonic stem cells (ESCs), very small embryonic-like stem cells (VSELs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs) in the treatment of various types of male infertility.
不育症已成为全球最常见的问题之一，对社会和不育夫妇产生了负面影响。同时，男性不育症约占不育症的 50%。因此，在过去的几年中，大量研究人员专注于其治疗方法；然而，目前的治疗方法，如辅助生殖技术（ART），在治疗男性不育症方面效果还不够理想。由于其自我更新和分化能力以及无限的来源，干细胞最近在治疗生殖系统疾病方面带来了很大的希望。干细胞是未分化的细胞，可以诱导产生不同数量的特定细胞，如雄性和雌性配子，这表明它们在治疗不育症方面具有潜在的应用。本综述旨在确定影响男性生育能力的原因和潜在因素。此外，我们还强调了最近的研究，这些研究调查了精原干细胞（SSCs）、胚胎干细胞（ESCs）、非常小的胚胎样干细胞（VSELs）、诱导多能干细胞（iPSCs）和间充质干细胞（MSCs）等干细胞在治疗各种类型男性不育症方面的效率。
