大鼠对手术手套上使用的脱模剂和润滑粉的长期腹膜组织反应。
Long-term peritoneal tissue response in rats to mould-release agents and lubricant powder used on surgeons' gloves.
作者信息
Pelling D, Evans J G
出版信息
Food Chem Toxicol. 1986 May;24(5):425-30. doi: 10.1016/0278-6915(86)90208-5.
Following implantation of 50-mg samples of a starch powder used for glove lubrication, or of talc or calcium carbonate mould-release agents for gloves, in the peritoneal cavity of rats, the treated animals were killed in groups of ten after 2, 4, 8, 13, 26 and 52 wk and were examined. Groups of sham-operated animals were used as controls. Within each treatment group the frequency of peritoneal adhesions remained constant throughout the study. Talc produced significantly more adhesions than the other treatments and caused a more severe granulomatous reaction, which persisted. Calcium carbonate and starch powder produced similar numbers of adhesions and in both cases the residues became invested by a thin fibrous capsule. Calcium carbonate appeared a safer material than talc.
将用于手套润滑的50毫克淀粉粉末样品，或用于手套的滑石粉或碳酸钙脱模剂植入大鼠腹腔后，在2周、4周、8周、13周、26周和52周后，每组10只处死经处理的动物并进行检查。假手术动物组用作对照。在整个研究过程中，每个治疗组内腹膜粘连的发生率保持不变。滑石粉产生的粘连明显多于其他治疗方法，并引起更严重的肉芽肿反应，且这种反应持续存在。碳酸钙和淀粉粉末产生的粘连数量相似，在这两种情况下，残留物都被一层薄纤维囊包裹。碳酸钙似乎是比滑石粉更安全的材料。
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