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银屑病和银屑病关节炎中的指甲超声——一篇叙述性综述

Nail Ultrasound in Psoriasis and Psoriatic Arthritis-A Narrative Review.

作者信息

Agache Mihaela, Popescu Claudiu C, Enache Luminița, Dumitrescu Bianca M, Codreanu Cătălin

机构信息

Department of Internal Medicine and Rheumatology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Clinical Center of Rheumatic Diseases, 030167 Bucharest, Romania.

出版信息

Diagnostics (Basel). 2023 Jun 30;13(13):2236. doi: 10.3390/diagnostics13132236.


DOI:10.3390/diagnostics13132236
PMID:37443629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10341279/
Abstract

Ultrasonography has advantages for assessing psoriatic arthritis (PsA) due to its ability to evaluate several targets, including joints, entheses, and tendons, but also skin and nails. Although ultrasound is widely used in PsA, nail ultrasound, despite its potential as a non-invasive method for the early detection of inflammation in the nail apparatus, has low applicability in medical practice, as probes with a higher frequency are needed compared with the frequency of probes usually used. In the present article, we have narratively evaluated the studies published in the last 5 years (19 February 2018-18 February 2023) on nail ultrasound value in the diagnosis and monitoring of PsA. The studies published during this period share common measurement parameters, such as the OMERACT definition of enthesis published in 2018. We included original articles published in PubMed and Web of Science using the following search terms in all possible combinations: psoriatic arthritis, psoriasis, ultrasound, and nail. Articles were declared relevant if they presented data on nail morphology, power Doppler evaluation and nearby structure evaluation, while focusing on digitorum extensor enthesitis. In most of the studies, common morphological parameters were generally increased in patients with psoriasis or PsA and were demonstrated to change with medication. The thickness of the extensor tendon was greater in patients with PsA and psoriasis versus controls and it was correlated with nail clinical changes, especially the presence of onycholysis. The presence of PD showed large variability in healthy individuals. The link between enthesitis and nail involvement is still a subject of controversy, taking into account the latest histological findings. The use of ultrasound in the evaluation of nail and DIP enthesitis remains a challenge and an area of research in the coming years.

摘要

超声检查在评估银屑病关节炎(PsA)方面具有优势,因为它能够评估多个目标,包括关节、附着点和肌腱,还能评估皮肤和指甲。尽管超声在PsA中被广泛应用,但指甲超声检查,尽管其作为一种非侵入性方法在早期检测甲床炎症方面具有潜力,但在医学实践中的适用性较低,因为与通常使用的探头频率相比,需要更高频率的探头。在本文中,我们对过去5年(2018年2月19日至2023年2月18日)发表的关于指甲超声在PsA诊断和监测中的价值的研究进行了叙述性评估。在此期间发表的研究共享了常见的测量参数,如2018年发表的附着点的OMERACT定义。我们纳入了在PubMed和Web of Science上发表的原始文章,使用以下搜索词的所有可能组合:银屑病关节炎、银屑病、超声和指甲。如果文章呈现了关于指甲形态、能量多普勒评估和附近结构评估的数据,同时关注指伸肌腱附着点炎,则被判定为相关。在大多数研究中,银屑病或PsA患者的常见形态学参数普遍增加,并被证明会随药物治疗而改变。与对照组相比,PsA和银屑病患者的伸肌腱厚度更大,并且与指甲临床变化相关,尤其是甲分离的存在。健康个体中能量多普勒的存在显示出很大的变异性。考虑到最新的组织学发现,附着点炎与指甲受累之间的联系仍然是一个有争议的话题。在未来几年,超声在评估指甲和远端指间关节附着点炎方面的应用仍然是一个挑战和研究领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39b3/10341279/6be3f4b88567/diagnostics-13-02236-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39b3/10341279/b25a79a57f09/diagnostics-13-02236-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39b3/10341279/6be3f4b88567/diagnostics-13-02236-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39b3/10341279/b25a79a57f09/diagnostics-13-02236-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39b3/10341279/6be3f4b88567/diagnostics-13-02236-g002.jpg

相似文献

[1]
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Diagnostics (Basel). 2023-6-30

[2]
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[3]
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[4]
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Radiol Med. 2022-12

[5]
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[6]
Ultrasound entheseal abnormalities at the distal interphalangeal joints and clinical nail involvement in patients with psoriasis and psoriatic arthritis, supporting the nail-enthesitis theory.

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[7]
Subclinical enthesopathy of extensor digitorum tendon is highly prevalent and associated with clinical and ultrasound alterations of the adjacent fingernails in patients with psoriatic disease.

J Eur Acad Dermatol Venereol. 2018-5-24

[8]
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[9]
Histological Evaluation of the Relationships Between Distal Interphalangeal Psoriatic Arthritis and Nail Psoriasis: Correlations With Anatomical Studies of the Normal Nail Unit and the Main Radiological Data Concerning Distal Interphalangeal Psoriatic Arthritis.

Am J Dermatopathol. 2020-12

[10]
The use of ultrasonography in the diagnosis of nail disease among patients with psoriasis and psoriatic arthritis: a systematic review.

Adv Rheumatol. 2019-9-5

引用本文的文献

[1]
Ultrasound Evaluation of Cosmetic Changes in Nails: A Case Series and Literature Review.

Cureus. 2025-7-11

[2]
Clinical and Ultrasonographic Assessment of Nail Psoriasis: A Comprehensive Study.

Dermatol Pract Concept. 2025-7-31

[3]
Ultrasound Beyond Joints: A Review of Extra-Articular Applications in Rheumatology.

Curr Rheumatol Rep. 2025-3-4

[4]
Ultrasonographic and power doppler parameters of nails fail to differentiate between onychodystrophy in patients with psoriasis vulgaris or psoriatic arthritis.

Adv Rheumatol. 2024-4-11

[5]
Correction: Agache et al. Nail Ultrasound in Psoriasis and Psoriatic Arthritis-A Narrative Review. 2023, , 2236.

Diagnostics (Basel). 2024-1-16

[6]
Assessment and Monitoring of Nail Psoriasis with Ultra-High Frequency Ultrasound: Preliminary Results.

Diagnostics (Basel). 2023-8-21

本文引用的文献

[1]
Are There Signs of Enthesitis in Nail Psoriasis? An Immunohistological Study of Nail Psoriasis With and Without Psoriatic Arthritis.

Am J Dermatopathol. 2023-1-1

[2]
Ultrasound Can Be Usefully Integrated with the Clinical Assessment of Nail and Enthesis Involvement in Psoriasis and Psoriatic Arthritis.

J Clin Med. 2022-10-26

[3]
Systematic study on nail plate assessment: differences in nail plate shape, thickness, power Doppler signal and scanning approach.

Arch Dermatol Res. 2023-4

[4]
Nail and enthesis assessment in patients with psoriatic disease by high frequency ultrasonography: findings from a single-centre cross-sectional study.

Radiol Med. 2022-12

[5]
Imaging of the nail unit in psoriatic patients:A systematic scoping review of techniques and terminology.

Exp Dermatol. 2022-6

[6]
Multimodal imaging of the distal interphalangeal-joint synovio-entheseal complex in psoriatic arthritis (MIDAS): a cross-sectional study on the diagnostic accuracy of different imaging modalities comparing psoriatic arthritis to psoriasis and osteoarthritis.

RMD Open. 2022-3

[7]
Integrating imaging and biomarker assessment to better define psoriatic arthritis and predict response to biologic therapy.

Rheumatology (Oxford). 2021-12-24

[8]
Secukinumab provides sustained improvement in nail psoriasis, signs and symptoms of psoriatic arthritis and low rate of radiographic progression in patients with concomitant nail involvement: 2-year results from the Phase III FUTURE 5 study.

Clin Exp Rheumatol. 2022-5

[9]
Apremilast improves quality of life and ultrasonography parameters in patients with nail psoriasis: A prospective cohort study.

J Dermatol. 2021-10

[10]
Ultrasonographic and resistance index evaluation of nails in psoriatic arthritis, psoriasis, and control groups: a cross-sectional study.

Adv Rheumatol. 2021-7-28

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