Macri Francesco, Khasanova Elina, Niu Bonnie T, Parakh Anushri, Patino Manuel, Kambadakone Avinash, Sahani Dushyant V
Department of Radiology, Geneva University Hospitals, University of Geneva, 1211 Geneva, Switzerland.
Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Diagnostics (Basel). 2023 Jul 5;13(13):2279. doi: 10.3390/diagnostics13132279.
We compared the image quality of abdominopelvic single-energy CT with 100 kVp (SECT-100 kVp) and dual-energy CT with 65 keV (DECT-65 keV) obtained with customized injection protocols to standard abdominopelvic CT scans (SECT-120 kVp) with fixed volumes of contrast media (CM). We retrospectively included 91 patients (mean age, 60.7 ± 15.8 years) with SECT-100 kVp and 83 (mean age, 60.3 ± 11.7 years) patients with DECT-65 keV in portovenous phase. Total body weight-based customized injection protocols were generated by a software using the following formula: patient weight (kg) × 0.40/contrast concentration (mgI/mL) × 1000. Patients had a prior abdominopelvic SECT-120 kVp with fixed injection. Iopamidol-370 was administered for all examinations. Quantitative and qualitative image quality comparisons were made between customized and fixed injection protocols. Compared to SECT-120 kVp, customized injection yielded a significant reduction in CM volume (mean difference = 9-12 mL; ≤ 0.001) and injection rate (mean differences = 0.2-0.4 mL/s; ≤ 0.001) in all weight categories. Improvements in attenuation, noise, signal-to-noise and contrast-to-noise ratios were observed for both SECT-100 kVp and DECT-65 keV compared to SECT-120 kVp in all weight categories (e.g., pancreas DECT-65 keV, 1.2-attenuation-fold increase vs. SECT-120 kVp; < 0.001). Qualitative scores were ≥4 in 172 cases (98.8.4%) with customized injections and in all cases with fixed injections (100%). These findings suggest that customized CM injection protocols may substantially reduce iodine dose while yielding higher image quality in SECT-100 kVp and DECT-65 keV abdominopelvic scans compared to SECT-120 kVp using fixed CM volumes.
我们将采用定制注射方案获得的100 kVp腹部盆腔单能量CT（SECT - 100 kVp）和65 keV双能量CT（DECT - 65 keV）的图像质量，与使用固定体积造影剂（CM）的标准腹部盆腔CT扫描（SECT - 120 kVp）进行比较。我们回顾性纳入了91例门静脉期接受SECT - 100 kVp检查的患者（平均年龄60.7±15.8岁）和83例接受DECT - 65 keV检查的患者（平均年龄60.3±11.7岁）。基于总体重的定制注射方案由软件使用以下公式生成：患者体重（kg）×0.40/造影剂浓度（mgI/mL）×1000。患者之前接受过固定注射的腹部盆腔SECT - 120 kVp检查。所有检查均使用碘帕醇 - 370。对定制注射方案和固定注射方案进行了定量和定性的图像质量比较。与SECT - 120 kVp相比，定制注射在所有体重类别中均使CM体积显著减少（平均差异 = 9 - 12 mL；P≤0.001），注射速率也显著降低（平均差异 = 0.2 - 0.4 mL/s；P≤0.001）。在所有体重类别中，与SECT - 120 kVp相比，SECT - 100 kVp和DECT - 65 keV的衰减、噪声、信噪比和对比噪声比均有所改善（例如，胰腺DECT - 65 keV，与SECT - 120 kVp相比衰减增加1.2倍；P < 0.001）。定制注射的172例（98.8.4%）和固定注射的所有病例（100%）的定性评分均≥4。这些发现表明，与使用固定CM体积的SECT - 120 kVp相比，定制CM注射方案可能会大幅降低碘剂量，同时在SECT - 100 kVp和DECT - 65 keV腹部盆腔扫描中产生更高的图像质量。
