Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Int J Mol Sci. 2023 Jun 29;24(13):10888. doi: 10.3390/ijms241310888.
This review article offers an outlook on the use of opioids as therapeutics for treating several diseases, including cancer and non-cancer pain, and focuses the analysis on the opportunity to target opioid receptors for treating opioid use disorder (OUD), drug withdrawal, and addiction. Unfortunately, as has been well established, the use of opioids presents a plethora of side effects, such as tolerance and physical and physiological dependence. Accordingly, considering the great pharmacological potential in targeting opioid receptors, the identification of opioid receptor ligands devoid of most of the adverse effects exhibited by current therapeutic agents is highly necessary. To this end, herein, we analyze some interesting molecules that could potentially be useful for treating OUD, with an in-depth analysis regarding in vivo studies and clinical trials.
这篇综述文章展望了阿片类药物作为治疗多种疾病（包括癌症和非癌症疼痛）的治疗方法的应用，并重点分析了针对阿片受体治疗阿片类药物使用障碍（OUD）、药物戒断和成瘾的机会。不幸的是，正如已经充分确立的那样，阿片类药物的使用存在诸多副作用，如耐受和身体及生理依赖。因此，考虑到靶向阿片受体具有巨大的药理学潜力，识别出大多数当前治疗药物所表现出的不良反应的阿片受体配体是非常必要的。为此，本文分析了一些可能对治疗 OUD 有用的有趣分子，并对体内研究和临床试验进行了深入分析。
