心得安阻断 CD-1 小鼠中未条件和条件性安非他命的过度兴奋效应。
Propranolol blocks the unconditioned and conditioned hyperactive effects of methamphetamine in CD-1 mice.
机构信息
Psychology Department and Neuroscience Program, Dickinson College, Carlisle, PA, USA.
出版信息
Behav Pharmacol. 2023 Sep 1;34(6):375-379. doi: 10.1097/FBP.0000000000000742. Epub 2023 Jul 14.
The present experiment examined the contribution of the β-adrenergic receptor system in mediating the unconditioned (i.e. pharmacological) and conditioned (i.e. learned) hyperactive effects of methamphetamine. To this end, mice underwent an 8-day conditioning procedure involving two different, alternating session types (chamber and home-cage days). On chamber days (1, 3, 5, and 7), mice were injected (intraperitoneally) with vehicle (dH 2 O) or propranolol (16 or 32 mg/kg) and were injected (subcutaneously) 30 min (min) later by either vehicle (saline; unpaired) or methamphetamine (1.0 mg/kg; paired). On home-cage days (2, 4, 6, and 8), mice were injected (subcutaneously) with either vehicle (saline; paired) or methamphetamine (1.0 mg/kg; unpaired) in their home cages. The test day for conditioned hyperactivity occurred 48 h after the last chamber day. Propranolol dose-dependently blocked the unconditioned and conditioned hyperactive effects of methamphetamine, implicating a role for the β-adrenergic system in mediating these effects of methamphetamine.
本实验研究了β-肾上腺素能受体系统在介导苯丙胺的非条件（即药理学）和条件（即学习）兴奋作用中的作用。为此，小鼠接受了为期 8 天的条件处理程序，涉及两种不同的、交替的会话类型（室和笼日）。在室日（1、3、5 和 7），小鼠接受腹腔注射（腹膜内）载体（dH2O）或普萘洛尔（16 或 32mg/kg），30 分钟后（min）皮下注射载体（生理盐水；非配对）或苯丙胺（1.0mg/kg；配对）。在笼日（2、4、6 和 8），小鼠在其笼中接受皮下注射载体（生理盐水；配对）或苯丙胺（1.0mg/kg；非配对）。条件性兴奋的测试日发生在最后一个室日的 48 小时后。普萘洛尔剂量依赖性地阻断了苯丙胺的非条件和条件兴奋作用，表明β-肾上腺素能系统在介导苯丙胺的这些作用中起作用。
Zotero 插件