长期使用氯氮平治疗的难治性精神分裂症患者的残疾状况与生活质量
Disability and quality of life in patients with treatment-resistant schizophrenia on long- term clozapine therapy.
作者信息
Nandakumar Dhandapani, Ganesh Ragul, Deb Koushik S, Jain Raka, Sood Mamta
机构信息
Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.
Department of Psychiatry, All India Institute of Medical Sciences, Vijaypur, Jammu and Kashmir, India.
出版信息
Indian J Psychiatry. 2023 Jun;65(6):694-697. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_320_22. Epub 2023 Jun 19.
OBJECTIVES
To assess disability and quality of life (QOL) in treatment resistant schizophrenia (TRS) on long term clozapine therapy and assess their correlation with positive, negative and cognitive symptoms.
METHODOLOGY
Disability and QOL in forty patients with TRS (as per modified Kane's criteria) were assessed using World Health Organization Disability Assessment Schedule 2.0 and World Health Organization Quality of Life-BREF. Scale for assessment of positive symptoms, scale for assessment of negative symptoms and Addenbrooke's cognitive examination-III were used to assess positive, negative and cognitive symptoms. Medication adherence rating scale assessed medication adherence.
RESULTS
Disability and QOL correlated significantly with medication adherence, negative and cognitive symptoms but not with positive symptoms. Subgroup analysis revealed significant difference between medication adherence (good vs poor) and cognitive (impairment vs non-impairment) groups.
CONCLUSION
Negative and cognitive symptoms, and medication adherence correlated with disability and QOL.
目的
评估长期使用氯氮平治疗的难治性精神分裂症（TRS）患者的残疾状况和生活质量（QOL），并评估它们与阳性、阴性及认知症状的相关性。
方法
使用世界卫生组织残疾评估量表2.0和世界卫生组织生活质量简表，对40例TRS患者（根据改良的凯恩标准）的残疾状况和生活质量进行评估。使用阳性症状评估量表、阴性症状评估量表和剑桥认知功能测试第三版来评估阳性、阴性和认知症状。用药依从性评定量表评估用药依从性。
结果
残疾状况和生活质量与用药依从性、阴性及认知症状显著相关，但与阳性症状无关。亚组分析显示，用药依从性（良好与不佳）组和认知（受损与未受损）组之间存在显著差异。
结论
阴性和认知症状以及用药依从性与残疾状况和生活质量相关。
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