Universidad Militar Nueva Granada, School of Medicine, Clinical Immunology Group, Bogotá, Colombia; Universidad El Bosque, Cellular and Molecular Immunology Group INMUBO, Bogotá, Colombia.
Universidad Militar Nueva Granada, School of Medicine, Clinical Immunology Group, Bogotá, Colombia.
Autoimmun Rev. 2023 Sep;22(9):103393. doi: 10.1016/j.autrev.2023.103393. Epub 2023 Jul 22.
Psoriatic arthritis (PsA) is an inflammatory complex condition. Posttranslational modifications influence almost all aspects of normal cell biology and pathogenesis. The aim of this systematic review was to collect all published evidence regarding posttranslational modifications in PsA, and the main outcome was to evaluate an association between disease outcomes and specific posttranslational modifications in PsA.
A systematic electronic search was performed in Medline, PubMed, Cochrane, Virtual Health Library, and Embase databases. A total of 587 articles were identified; 59 were evaluated after removing duplicates and scanning, of which 47 were included. A descriptive analysis was conducted, with results grouped according to the type of posttranslational modification evaluated. The protocol was registered at the PROSPERO database.
Seven posttranslational modifications were identified: citrullination, carbamylation, phosphorylation, glycosylation, acetylation, methylation, and oxidative stress. Anti-citrullinated peptide and anti-carbamylated protein have been evaluated in rheumatoid arthritis. There is now information suggesting that these antibodies may be helpful in improving the diagnosis of PsA and that they may demonstrate a correlation with worse disease progression (erosions, polyarticular involvement, and poor treatment response). Glycosylation was associated with increased inflammation and phosphorylation products related to the expression of SIRT2 and pSTAT3 or the presence of Th17 and cytokine interleukin-22, suggesting a possible therapeutic target.
Posttranslational modifications often play a key role in modulating protein function in PsA and correlate with disease outcomes. Citrullination, carbamylation, phosphorylation, glycosylation, acetylation, methylation, and oxidative stress were identified as associated with diagnosis and prognosis.
银屑病关节炎（PsA）是一种炎症性复杂疾病。翻译后修饰几乎影响正常细胞生物学和发病机制的各个方面。本系统评价的目的是收集所有关于 PsA 翻译后修饰的已发表证据，主要结果是评估疾病结局与 PsA 中特定翻译后修饰之间的关联。
在 Medline、PubMed、Cochrane、Virtual Health Library 和 Embase 数据库中进行系统的电子检索。共确定了 587 篇文章；在去除重复项并扫描后评估了 59 篇，其中 47 篇被纳入。进行了描述性分析，结果根据评估的翻译后修饰类型进行分组。该方案在 PROSPERO 数据库中进行了注册。
确定了七种翻译后修饰：瓜氨酸化、氨甲酰化、磷酸化、糖基化、乙酰化、甲基化和氧化应激。抗瓜氨酸肽和抗氨甲酰化蛋白已在类风湿关节炎中进行了评估。现在有信息表明，这些抗体可能有助于改善 PsA 的诊断，并且它们可能与更严重的疾病进展（侵蚀、多关节受累和治疗反应不佳）相关。糖基化与炎症增加有关，磷酸化产物与 SIRT2 和 pSTAT3 的表达或 Th17 和细胞因子白细胞介素-22 的存在有关，这表明可能是一个治疗靶点。
翻译后修饰通常在调节 PsA 中蛋白质功能方面发挥关键作用，并与疾病结局相关。瓜氨酸化、氨甲酰化、磷酸化、糖基化、乙酰化、甲基化和氧化应激与诊断和预后相关。
