Anim-Koranteng Comfort, Akpoigbe Okeoghene, Miller Michael, Averbukh Yelena
Internal Medicine, Harlem Hospital Center, New York, USA.
Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, USA.
Cureus. 2023 Jun 22;15(6):e40825. doi: 10.7759/cureus.40825. eCollection 2023 Jun.
Immune-mediated necrotizing myopathy is a subtype of immune-mediated myopathy associated with or without statin use. Statins, or HMG-CoA reductase inhibitors, are the most prescribed medications for dyslipidemia. The statin-associated myopathic syndromes range from asymptomatic elevations in creatine kinase to severe debilitating muscle weakness with associated rhabdomyolysis and elevated liver enzymes. Clinical improvement occurs upon discontinuation of statins, but some patients do not recover completely. Diagnostic tests include electromyography, muscle biopsy, myositis autoantibody panel, and antibodies against the HMGCR. Here, we present a case of anti-HMGCR-related myopathy associated with atorvastatin.
免疫介导的坏死性肌病是免疫介导性肌病的一种亚型,与使用或未使用他汀类药物有关。他汀类药物,即HMG-CoA还原酶抑制剂,是治疗血脂异常最常用的药物。他汀类药物相关的肌病综合征范围从肌酸激酶无症状升高到严重的使人衰弱的肌肉无力,并伴有横纹肌溶解和肝酶升高。停用他汀类药物后临床症状会改善,但一些患者不能完全恢复。诊断检查包括肌电图、肌肉活检、肌炎自身抗体检测以及抗HMGCR抗体检测。在此,我们报告一例与阿托伐他汀相关的抗HMGCR相关性肌病病例。