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奥沙利铂诱发的视乳头水肿:罕见病例报告。

Oxaliplatin-induced papilledema: Rare case report.

作者信息

Jayasri P, Stephen A M, Harigaravelu P J

机构信息

Department of Ophthalmology, GVMC, Chennai, Tamil Nadu, India.

出版信息

Saudi J Ophthalmol. 2023 May 26;37(2):161-163. doi: 10.4103/sjopt.sjopt_27_22. eCollection 2023 Apr-Jun.

Abstract

Papilledema is the presence of bilateral optic disc edema in the presence of raised intracranial pressure and often is symmetric. We report a case of a 70-year-old male with rectal carcinoma on chemotherapy presented with minimal drop in visual acuity. The patient has bilateral disc edema and investigations including computed tomography and cerebrospinal fluid opening pressure were normal and no evidence of brain metastasis has been found. The patient was on oxaliplatin regimen and literature search has shown very few cases of platinum chemotherapy agents-induced papilledema. So far to our knowledge, oxaliplatin-induced papilledema has not been reported and knowing this condition can be sight saving for ill patients.

摘要

视乳头水肿是指在颅内压升高时出现的双侧视盘水肿,通常是对称的。我们报告一例70岁男性直肠癌患者,在化疗过程中视力仅有轻微下降。该患者双侧视盘水肿,包括计算机断层扫描和脑脊液开放压在内的检查均正常,未发现脑转移证据。患者正在接受奥沙利铂方案化疗,文献检索显示铂类化疗药物引起视乳头水肿的病例非常少。据我们所知,迄今为止尚未有奥沙利铂引起视乳头水肿的报道,了解这种情况对患病患者可能挽救视力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab66/10365248/c6c2e5dbd497/SJO-37-161-g001.jpg

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