持续气道正压通气治疗对听觉事件相关电位 P300 的影响。
INFLUENCE OF CONTINUOUS POSITIVE AIRWAY PRESSURE TREATMENT ON AUDITORY EVENT-RELATED POTENTIALS P300.
机构信息
Department of Neurology, University Hospital Center Osijek, Osijek, Croatia.
Department of Neurology and Neurosurgery, Faculty of Medicine Osijek, J. J. Strossmayer University, Osijek, Croatia.
出版信息
Acta Clin Croat. 2022 Nov;61(3):373-378. doi: 10.20471/acc.2022.61.03.01.
Obstructive sleep apnea (OSA) is a sleep-related breathing disorder characterized by obstructions of the upper airway during sleep, resulting in repetitive breathing pauses accompanied by oxygen desaturation and arousal from sleep. OSA can be successfully treated with continuous positive airway pressure (CPAP), weight loss, positional therapy, oral appliances, hypoglossal nerve stimulation, and surgical procedures. It has been observed that untreated OSA is related to chronic disorders including hypertension, arrhythmias, congestive heart failure, coronary heart disease, diabetes mellitus, hyperlipidemia, stroke, depression, and cognitive decline. Event-related potentials (ERPs) is the procedure that has been widely used for evaluating cognitive brain functions. Using auditory event-related potentials (P300), this study aimed to examine the effect of CPAP therapy on cognitive functions in patients with moderate and severe OSA. The results of the study showed improvement in P300 latency and amplitude after 3 months of CPAP therapy, indicating a positive effect of CPAP therapy in the prevention of cognitive decline in patients with OSA.
阻塞性睡眠呼吸暂停（OSA）是一种与睡眠相关的呼吸障碍，其特征是睡眠期间上呼吸道阻塞，导致呼吸暂停，伴有氧饱和度下降和睡眠觉醒。阻塞性睡眠呼吸暂停可以通过持续气道正压通气（CPAP）、减肥、体位治疗、口腔器械、舌下神经刺激和手术治疗得到有效治疗。研究发现，未经治疗的 OSA 与包括高血压、心律失常、充血性心力衰竭、冠心病、糖尿病、高脂血症、中风、抑郁和认知能力下降在内的慢性疾病有关。事件相关电位（ERPs）是一种广泛用于评估认知脑功能的方法。本研究采用听觉事件相关电位（P300），旨在研究 CPAP 治疗对中重度 OSA 患者认知功能的影响。研究结果表明，CPAP 治疗 3 个月后 P300 潜伏期和振幅改善，表明 CPAP 治疗对 OSA 患者认知能力下降有积极的预防作用。
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