Hartson-Eaton M, Hornback N B
Radiat Res. 1986 Sep;107(3):287-95.
The amount and type of interaction between heat and radiation are evaluated for several sets of experiments using Chinese hamster ovary cells, subline HA-1, through the interaction coefficient derived by Roti Roti and Henle. As the duration of postradiation heat treatment is increased from 15 min to 2 h, the amount of interaction increases linearly with heating time from 15 to 60 min. From 60 to 120 min the amount of interaction remains relatively constant. For a given heat treatment the amount of interaction increases linearly with radiation dose over four decades of survival when the X-ray treatment immediately follows the heat treatment. The additivity of heat and radiation is also analyzed by use of the envelope of additivity method suggested by Steel and Peckham. The results imply that heat and radiation are not superadditive which suggests that this analysis is inapplicable to the interaction of these two modalities. Several possible reasons for the failure of this analysis are discussed.
通过Roti Roti和Henle推导的相互作用系数，对使用中国仓鼠卵巢细胞亚系HA-1进行的几组实验评估了热与辐射之间相互作用的量和类型。随着辐射后热处理时间从15分钟增加到2小时，相互作用量在加热时间从15分钟到60分钟时随加热时间呈线性增加。从60分钟到120分钟，相互作用量保持相对恒定。对于给定的热处理，当X射线处理紧接在热处理之后时，相互作用量在四个数量级的存活率范围内随辐射剂量呈线性增加。还使用Steel和Peckham提出的相加性包络线方法分析了热与辐射的相加性。结果表明热与辐射不是超相加的，这表明该分析不适用于这两种方式的相互作用。讨论了该分析失败的几个可能原因。
