Loni Ramaning, Zameer Sara, Hasan Fareedul Ahmed, Abbas Ittrat, Mesrati Hager, George John, Fox Gabriel, Dey Arjun C, Finan Alan
Department of Pediatrics, King Hamad University Hospital, Bahrain.
Indian J Crit Care Med. 2023 Jul;27(7):503-509. doi: 10.5005/jp-journals-10071-24486.
To study if 25-hydroxy cholecalciferol levels correlate with clinical outcomes in a cohort of critically ill children requiring pediatric intensive care unit (PICU) admission.
All children between the ages of 1 month and 14 years admitted to a PICU were included in this study. The vitamin-D level was measured within 24 hours of admission to the PICU for each patient. The patient's clinical details, vitamin-D levels, and biochemical parameters were collected.
There were 119 critically ill children (47 females and 72 males) admitted to our PICU. A total of 56 children were in the vitamin-D-deficient group, giving a prevalence of 47.05%. Sixty-three children had either insufficient or normal levels of 25(OH)D. Mean serum 25-OH cholecalciferol was 22.82 ± 16.48 nmol/L. There were no significant differences in O2 utilization, ventilation requirement, length of PICU stay, or the frequencies of use of antibiotics and steroids between the groups. The overall mortality rate in this study was 5.8% (three children died in the deficient group as compared with four in the insufficient/normal group).
Even though vitamin-D deficiency was highly prevalent in the PICU, there were no statistically significant differences in O2 utilization, length of PICU stay, duration of mechanical ventilation, the use of antibiotics/steroids, and mortality outcome for both deficient and insufficient/normal groups.
Loni R, Zameer S, Hasan FA, Abbas I, Mesrati H, George J, . Vitamin-D Status and Clinical Outcomes in Critically Ill Children. Indian J Crit Care Med 2023;27(7):503-509.
研究在一批需要入住儿科重症监护病房（PICU）的危重症儿童中，25-羟胆钙化醇水平与临床结局是否相关。
本研究纳入了所有入住PICU的1个月至14岁儿童。对每位患者在入住PICU的24小时内测量维生素D水平。收集患者的临床详细信息、维生素D水平和生化参数。
共有119名危重症儿童（47名女性和72名男性）入住我们的PICU。共有56名儿童处于维生素D缺乏组，患病率为47.05%。63名儿童的25(OH)D水平不足或正常。血清25-羟胆钙化醇平均水平为22.82±16.48 nmol/L。两组之间在氧气利用、通气需求、PICU住院时间或抗生素和类固醇的使用频率方面没有显著差异。本研究的总体死亡率为5.8%（缺乏组有3名儿童死亡，不足/正常组有4名儿童死亡）。
尽管PICU中维生素D缺乏非常普遍，但维生素D缺乏组和不足/正常组在氧气利用、PICU住院时间、机械通气持续时间、抗生素/类固醇的使用以及死亡率结局方面没有统计学上的显著差异。
洛尼R，扎米尔S，哈桑FA，阿巴斯I，梅斯拉蒂H，乔治J，等。危重症儿童的维生素D状态与临床结局。《印度重症监护医学杂志》2023；27(7)：503 - 509。
