Lee Saeyoung, Song Woo-Jin, Park Jongjin, Kim Minkun, Choen Sangkyung, Kim Myung-Chul, Jeong Hyohoon, Yun Youngmin
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Jeju National University, Jeju 63243, Republic of Korea.
The Research Institute of Veterinary Science, College of Veterinary Medicine, Jeju National University, Jeju 63243, Republic of Korea.
Vet Sci. 2023 Jul 5;10(7):438. doi: 10.3390/vetsci10070438.
An 8-year-old, castrated male Shih-tzu dog (Case 1) showing ataxia and gait disorder was referred for neurological examination and magnetic resonance imaging. Through comprehensive examinations, the patient was tentatively diagnosed with meningoencephalitis of unknown origin (MUO) and treatment with prednisolone and cytosine arabinoside was started. The symptoms were improving with immunosuppressive treatment. However, severe bacterial cystitis occurred and we could not avoid tapering off prednisolone. Then, neurological signs recurred. Therefore, we added crisdesalazine, which allowed us to reduce the daily dosage of immunosuppressants easily. In another case, a 4-year-old, spayed female Yorkshire terrier dog (Case 2) was referred to our hospital showing a head tilt, circling, and loss of the menace reflex. The patient was tentatively diagnosed with MUO and treatment with some immunosuppressants was attempted. The clinical symptoms improved, but the alleviation was inadequate. Thus, we added crisdesalazine. The neurological signs then markedly improved. Moreover, the drugs could be tapered off more easily than before. Crisdesalazine is a novel drug that has antioxidant and anti-inflammatory action in brain disease and is used particularly for dementia. In this paper, we tried an off-label use of this drug in canine MUO patients, and found that it had, in these two patients, additional therapeutic effects on the MUO.
一只8岁去势雄性西施犬（病例1）出现共济失调和步态障碍，被转诊进行神经学检查和磁共振成像。通过全面检查，该患者初步诊断为不明原因脑膜脑炎（MUO），并开始使用泼尼松龙和阿糖胞苷治疗。免疫抑制治疗后症状有所改善。然而，严重的细菌性膀胱炎发生，我们不得不逐渐减少泼尼松龙的用量。随后，神经症状复发。因此，我们加用了柳氮磺胺吡啶，这使得我们能够轻松减少免疫抑制剂的每日剂量。在另一个病例中，一只4岁去势雌性约克夏梗犬（病例2）因出现头部倾斜、转圈和威胁反射消失被转诊至我院。该患者初步诊断为MUO，并尝试使用了一些免疫抑制剂进行治疗。临床症状有所改善，但缓解并不充分。因此，我们加用了柳氮磺胺吡啶。随后神经症状明显改善。此外，药物减量比以前更容易。柳氮磺胺吡啶是一种在脑部疾病中具有抗氧化和抗炎作用的新药，尤其用于治疗痴呆症。在本文中，我们尝试在犬类MUO患者中对该药物进行了超说明书用药，发现它在这两名患者中对MUO具有额外的治疗效果。
