贝拉前列腺素与慢性肾病猫的总生存率
Beraprost and Overall Survival in Cats with Chronic Kidney Disease.
作者信息
Ito Hiroyuki, Matsuura Takumi, Sano Tadashi
机构信息
Ichikawa General Hospital, Kariya Animal Hospital Group, Chiba 272-0034, Japan.
Toray Industries, Inc., Tokyo 103-8666, Japan.
出版信息
Vet Sci. 2023 Jul 13;10(7):459. doi: 10.3390/vetsci10070459.
BACKGROUND
Overall survival is the most important outcome for treatment response in feline chronic kidney disease (CKD). Beraprost has been shown to reduce the kidney function decline in cats with International Renal Interest Society (IRIS) stage 2 and 3 CKD. However, the association with prolonged survival has not yet been examined.
OBJECTIVE
To assess the relationship between beraprost and overall survival in cats with CKD in real clinical practice.
ANIMALS
Client-owned cats with IRIS stage 3 CKD ( = 134) were evaluated between 2017 and 2020.
METHODS
A retrospective cohort study based on data from electronic medical records of one hospital.
RESULTS
The cohort was divided into "beraprost therapy" and "no beraprost therapy" groups, and survival analyses revealed that overall survival was significantly longer in the beraprost therapy group, using Kaplan-Meier curves ( = 0.004). However, baseline phosphate is known to be an important prognostic indicator and was not well balanced between the two groups. Therefore, a subcohort of 97 cats was selected (those having baseline phosphate <6.0 mg/dL) that allowed for this parameter to be balanced between groups. The survival data in this subcohort were consistent with those of the overall study cohort.
CONCLUSIONS
In feline patients with CKD, beraprost therapy is associated with better overall survival.
背景
总生存期是猫慢性肾病（CKD）治疗反应的最重要结果。已证明贝拉前列腺素可减缓国际肾脏兴趣协会（IRIS）2期和3期CKD猫的肾功能下降。然而，其与延长生存期的关联尚未得到研究。
目的
评估在实际临床实践中，贝拉前列腺素与CKD猫总生存期之间的关系。
动物
2017年至2020年期间对134只IRIS 3期CKD的客户拥有猫进行了评估。
方法
基于一家医院电子病历数据的回顾性队列研究。
结果
该队列被分为“贝拉前列腺素治疗组”和“未用贝拉前列腺素治疗组”，生存分析显示，使用Kaplan-Meier曲线，贝拉前列腺素治疗组的总生存期显著更长（P = 0.004）。然而，已知基线磷酸盐是一个重要的预后指标，且两组之间该指标不均衡。因此，选择了97只猫的亚队列（基线磷酸盐<6.0 mg/dL的猫），以使该参数在组间达到平衡。该亚队列的生存数据与整个研究队列的数据一致。
结论
在患有CKD的猫科动物患者中，贝拉前列腺素治疗与更好的总生存期相关。
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