Jaramillo-Rangel Gilberto, Chávez-Briones María-de-Lourdes, Ancer-Arellano Adriana, Miranda-Maldonado Ivett, Ortega-Martínez Marta
Department of Pathology, School of Medicine, Autonomous University of Nuevo León, Monterrey 64460, Mexico.
Biomedicines. 2023 Jul 24;11(7):2075. doi: 10.3390/biomedicines11072075.
Aging-related molecular and cellular alterations in the lung contribute to an increased susceptibility of the elderly to devastating diseases. Although the study of the aging process in the lung may benefit from the use of genetically modified mouse models and omics techniques, these approaches are still not available to most researchers and produce complex results. In this article, we review works that used naturally aged mouse models, together with immunohistochemistry (IHC) and quantitative morphologic (QM) methods in the study of the mechanisms of the aging process in the lung and its most commonly associated disorders: cancer, chronic obstructive pulmonary disease (COPD), and infectious diseases. The advantage of using naturally aged mice is that they present characteristics similar to those observed in human aging. The advantage of using IHC and QM methods lies in their simplicity, economic accessibility, and easy interpretation, in addition to the fact that they provide extremely important information. The study of the aging process in the lung and its associated diseases could allow the design of appropriate therapeutic strategies, which is extremely important considering that life expectancy and the number of elderly people continue to increase considerably worldwide.
肺部与衰老相关的分子和细胞改变会导致老年人更容易患上严重疾病。虽然肺部衰老过程的研究可能受益于基因改造小鼠模型和组学技术的应用，但大多数研究人员仍然无法使用这些方法，而且这些方法会产生复杂的结果。在本文中，我们回顾了在肺部衰老过程及其最常见相关疾病（癌症、慢性阻塞性肺疾病（COPD）和传染病）机制研究中使用自然衰老小鼠模型以及免疫组织化学（IHC）和定量形态学（QM）方法的研究成果。使用自然衰老小鼠的优势在于它们呈现出与人类衰老过程中观察到的特征相似的特点。使用IHC和QM方法的优势在于其简单性、经济可行性和易于解读，此外，它们还能提供极其重要的信息。对肺部衰老过程及其相关疾病的研究有助于设计合适的治疗策略，鉴于全球范围内预期寿命和老年人数量持续大幅增加，这一点极为重要。
