三亲子半同胞测试分析。
Analysis of Trio Half Sibling Testing.
机构信息
Department of Criminal Technology, Guangdong Police College, Guangzhou 510000, China.
Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510089, China.
出版信息
Fa Yi Xue Za Zhi. 2023 Jun 25;39(3):254-261. doi: 10.12116/j.issn.1004-5619.2021.511202.
OBJECTIVES
To establish an analytical method for half sibling testing involving common three relatives' participation.
METHODS
Based on the half sibling testing scenarios with the known biological mother, grandfather or uncle, and two unidentified controversial half siblings participating, two opposing hypotheses were set. Lineage reconstruction according to Mendel's law of heredity was carried out, and the calculation formula of the half sibling kinship index was derived. Verification of actual cases was carried out and the results were compared with duo half sibling testing.
RESULTS
In the scenarios of the known biological mother, grandfather and uncle participating in half sibling testing, the kinship calculation formulae of 54, 91 and 99 genotype combinations for kinship index calculation were deduced respectively. The actual cases showed higher kinship indexes in trio half sibling testing compared with duo half sibling testing.
CONCLUSIONS
It is beneficial to obtain more genetic information for family reconstruction and improvement of the strength of genetic evidence for half sibling testing by adding known relatives.
目的
建立一种涉及常见三亲参与的半同胞检测分析方法。
方法
基于已知生母、祖父或叔叔以及两个身份不明的有争议半同胞参与的半同胞检测场景，设置了两个对立的假设。根据孟德尔遗传定律进行系谱重建，并推导出半同胞亲缘指数的计算公式。进行实际案例验证，并将结果与双半同胞检测进行比较。
结果
在已知生母、祖父和叔叔参与半同胞检测的场景中，分别推导出了 54、91 和 99 种基因型组合的亲缘指数计算公式。实际案例表明，三对半同胞检测的亲缘指数高于双对半同胞检测。
结论
通过添加已知亲属，可以为家庭重建提供更多的遗传信息，并提高半同胞检测的遗传证据强度。
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