Boretos J W, Sullivan J V, Fitze P E, Girton M E, Doppman J L
Ann Biomed Eng. 1986;14(4):323-38. doi: 10.1007/BF02367406.
A new catheter of dual lumen construction, suitable for clinical use, is capable of navigating acute vessel branches by selective retrojet fluid thrusts issuing from cowlings built into its distal sidewalls. Conventional radiopaque liquids can be used both to drive the system and to fluoroscopically locate its position relative to the vascular network. In vitro studies have shown the catheter to traverse straight vessels and negotiate difficult lateral turns over short radii in the process of entering progressively smaller branches. In vivo studies have verified these capabilities and suggest a means for embolizing tumors and arteriovenous malformations located at otherwise inaccessible regions. For arterial infusion of drugs to treat tumors, the turbulent jet action is utilized to enhance mixing within the blood stream to overcome the streaming phenomenon common to other catheters. The result is better distribution of the agent and increased opportunity for the drug to reach more of the tumor. The catheter system is undergoing clinical trials.
一种新型双腔结构导管,适用于临床,通过从其远端侧壁内置的整流罩喷出的选择性反向喷射液流推力,能够在急性血管分支中导航。传统的不透射线液体可用于驱动该系统,并通过荧光透视确定其相对于血管网络的位置。体外研究表明,该导管在进入逐渐变细的分支过程中能够穿过直血管并在短半径内通过困难的侧向转弯。体内研究已经证实了这些能力,并提出了一种栓塞位于其他难以到达区域的肿瘤和动静脉畸形的方法。对于动脉内注射药物治疗肿瘤,利用湍流喷射作用增强血流中的混合,以克服其他导管常见的层流现象。结果是药物分布更好,药物到达更多肿瘤的机会增加。该导管系统正在进行临床试验。