Rosa G, Orfei P, Sanfilippo M, Vilardi V, Gasparetto A
Anesth Analg. 1986 Apr;65(4):381-4.
Twenty-five patients with expansive pathologic brain lesions, who were anesthetized with thiopental, nitrous oxide in oxygen, and fentanyl, and who were mechanically ventilated to ensure normocarbia, received atracurium besylate 0.6 mg/kg, intravenously. Intracranial pressure, mean arterial pressure, central venous pressure, heart rate, and end-tidal CO2 were simultaneously recorded for 5 min before and for 10 min after administration of the muscle relaxant. No statistically significant changes were observed after administration of atracurium besylate. These results suggest that atracurium besylate may be used for muscle relaxation during neurosurgical operations, despite its potential for histamine release and excitement of the central nervous system.
25例患有扩展性病理性脑损伤的患者，使用硫喷妥钠、氧化亚氮和芬太尼进行麻醉，并进行机械通气以确保正常碳酸血症，静脉注射0.6mg/kg的苯磺顺阿曲库铵。在给予肌肉松弛剂之前5分钟和之后10分钟同时记录颅内压、平均动脉压、中心静脉压、心率和呼气末二氧化碳。给予苯磺顺阿曲库铵后未观察到统计学上的显著变化。这些结果表明，尽管苯磺顺阿曲库铵有释放组胺和兴奋中枢神经系统的可能性，但它仍可用于神经外科手术中的肌肉松弛。
