神经甾体治疗产后抑郁症的神经内分泌学见解。
Neuroendocrine insights into neurosteroid therapy for postpartum depression.
机构信息
Department of Neuroscience and Experimental Therapeutics, Texas A&M University School of Medicine, Bryan, TX 77807, USA; Texas A&M Health Institute of Pharmacology and Neurotherapeutics, Texas A&M University Health Science Center, Bryan, TX 77807, USA.
出版信息
Trends Mol Med. 2023 Dec;29(12):979-982. doi: 10.1016/j.molmed.2023.07.006. Epub 2023 Aug 2.
Abstract
Postpartum depression (PPD) is associated with a decline in progesterone-derived anxiolytic-antidepressant neurosteroids after delivery. Neurosteroid replacement therapy (NRT) with GABA-A receptor-modulating allopregnanolone (brexanolone) shows promise as the first drug treatment for PPD. Here we describe the molecular insights of the neurosteroid approach for rapid relief of PPD symptoms compared with traditional antidepressants.
摘要
产后抑郁症（PPD）与分娩后孕激素衍生的抗焦虑-抗抑郁神经甾体的下降有关。GABA-A 受体调节神经甾体（别孕烯醇酮）的神经甾体替代疗法（NRT）有望成为 PPD 的第一种药物治疗方法。在这里，我们描述了与传统抗抑郁药相比，神经甾体方法快速缓解 PPD 症状的分子见解。
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