Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Beijing Anding Hospital, Capital Medical University, Beijing, China; The National Clinical Research Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing, China.
J Affect Disord. 2023 Nov 1;340:280-289. doi: 10.1016/j.jad.2023.08.036. Epub 2023 Aug 6.
The aim of this study was to assess brain functional alterations in BN patients with affective disorders and their association with maladaptive eating behaviors.
A total of 42 BN patients with affective disorders (anxiety and depression) and 47 healthy controls (HCs) were enrolled in this study. The resting-state fMRI data were analyzed for functional changes as indicated by regional homogeneity based on Kendall's coefficient of concordance (KCC-ReHo) and seed-based functional connectivity (FC). A principal component analysis (PCA) model was used to identify the commonalities within the behavioral questionnaires from the BN group.
Patients in the BN group showed decreased ReHo in the bilateral middle frontal gyrus (MFG) and right supramarginal gyrus (SMG). Additionally, the BN group showed increased FC between the left MFG and the right inferior temporal gyrus (ITG); decreased FC between the right MFG and the bilateral insula and the left middle temporal gyrus (MTG); and decreased FC between the right SMG and the left superior temporal gyrus (STG) and right inferior frontal gyrus (IFG). In the FC-behavior association analysis, the second principal component (PC2) was negatively correlated with FC between the left MFG and the right ITG.
Based on a brain functional analysis (ReHo and FC), this study revealed significant aberrant changes in the frontal-temporal regions of BN patients with affective disorders. These regions, which serve as fronto-temporal circuitry, are associated with restraint and emotional eating behaviors. Our findings shed new light on the neural mechanisms underlying the condition.
本研究旨在评估伴发情感障碍的 BN 患者的脑功能改变及其与不良进食行为的关系。
本研究纳入了 42 例伴发情感障碍（焦虑和抑郁）的 BN 患者和 47 例健康对照者（HCs）。采用基于 Kendall 协和系数（KCC-ReHo）的局部一致性和基于种子点的功能连接（FC）分析静息态 fMRI 数据，以评估功能变化。采用主成分分析（PCA）模型识别 BN 组行为问卷的共性。
BN 组患者双侧额中回（MFG）和右侧缘上回（SMG）的 ReHo 降低。此外，BN 组左侧 MFG 与右侧颞下回（ITG）之间的 FC 增加；右侧 MFG 与双侧岛叶和左侧颞中回（MTG）之间的 FC 降低；右侧 SMG 与左侧颞上回（STG）和右侧额下回（IFG）之间的 FC 降低。在 FC-行为关联分析中，第二主成分（PC2）与左侧 MFG 与右侧 ITG 之间的 FC 呈负相关。
基于脑功能分析（ReHo 和 FC），本研究揭示了伴发情感障碍的 BN 患者额颞区存在显著的异常改变。这些作为额颞回路的区域与控制和情绪进食行为有关。我们的研究结果为该疾病的神经机制提供了新的见解。
