结直肠癌与营养质量指数（INQ）的相关性：一项病例对照研究。
THE ASSOCIATION BETWEEN COLORECTAL CANCER AND INDEX OF NUTRITIONAL QUALITY (INQ); A CASE-CONTROL STUDY.
机构信息
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
出版信息
Arq Gastroenterol. 2023 Apr-Jun;60(2):217-223. doi: 10.1590/S0004-2803.20230222-169.
•Is the Index of Nutritional Quality (INQ) associated with colon cancer? •This study compared the INQ of various dietary components between colorectal cancer patients and healthy controls. A total of 480 participants were enrolled in the study (160 patients with colorectal cancer as a case group and 320 healthy control). The results showed that CRC is significantly associated with INQ for some micronutrients. INQ can be considered as an indicator to assess clinical nutritional problems. Background - The nutritional quality of diet may influence the risk of colorectal cancer (CRC). This study compared the Index of Nutritional Quality (INQ) of various dietary components between colorectal cancer patients and healthy controls. Methods - A total of 480 participants were enrolled in the study (160 patients with colorectal cancer as a case group and 320 healthy control). An analysis was conducted on the general characteristics of the participants, their medical histories, anthropometric indicators, physical activity, alcohol consumption, reproductive history, smoking and food intake. A valid food frequency questionnaire was used to assess nutrient intake and INQ was calculated from daily nutrient intake. Results - A Significant inverse association was found between CRC and INQ for vitamins A (OR=0.01, CI: 0.01-0.01), K (OR=0.04, CI: 0.01-0.15), and B12 (OR=0.71, CI: 0.51-0.98), B5 (OR=0.43, CI: 0.00-0.01), zinc (OR=0.35, CI: 0.13-0.95), and phosphorus (OR=0.17, 0.19-0.94). The association between the INQ of vitamin B12 and zinc with colorectal cancer was disappeared after age adjustment. There was a significant negative association between CRC with the INQ of vitamins A, K, B5, phosphorus, and calcium after further adjustments for gender, BMI, menopausal status, and total energy intake. Conclusion -CRC is significantly associated with INQ for some micronutrients. INQ can be considered as an indicator to assess clinical nutritional problems.
•营养质量指数（INQ）与结肠癌有关吗？•本研究比较了结肠癌患者和健康对照组各种饮食成分的 INQ。共有 480 名参与者纳入研究（160 名结肠癌患者为病例组，320 名健康对照）。结果表明，CRC 与某些微量营养素的 INQ 显著相关。INQ 可作为评估临床营养问题的指标。背景：饮食的营养质量可能会影响结直肠癌（CRC）的风险。本研究比较了结肠癌患者和健康对照组各种饮食成分的营养质量指数（INQ）。方法：共有 480 名参与者纳入研究（160 名结肠癌患者为病例组，320 名健康对照）。对参与者的一般特征、病史、人体测量指标、体力活动、饮酒、生育史、吸烟和食物摄入量进行了分析。采用有效的食物频率问卷评估营养素摄入量，并根据每日营养素摄入量计算 INQ。结果：CRC 与维生素 A（OR=0.01，CI：0.01-0.01）、K（OR=0.04，CI：0.01-0.15）、B12（OR=0.71，CI：0.51-0.98）、B5（OR=0.43，CI：0.00-0.01）、锌（OR=0.35，CI：0.13-0.95）和磷（OR=0.17，0.19-0.94）的 INQ 呈显著负相关。调整年龄后，维生素 B12 和锌的 INQ 与结直肠癌的相关性消失。进一步调整性别、BMI、绝经状态和总能量摄入后，维生素 A、K、B5、磷和钙的 INQ 与 CRC 呈显著负相关。结论：CRC 与某些微量营养素的 INQ 显著相关。INQ 可作为评估临床营养问题的指标。
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