United Kingdom Dementia Research Institute at The University of Edinburgh, Edinburgh Medical School, Edinburgh, EH16 4SB, UK; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH16 4SB, UK.
United Kingdom Dementia Research Institute at The University of Edinburgh, Edinburgh Medical School, Edinburgh, EH16 4SB, UK; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK.
Neurobiol Dis. 2023 Sep;185:106255. doi: 10.1016/j.nbd.2023.106255. Epub 2023 Aug 7.
Brain metabolic pathways relating to bioenergetic and redox homeostasis are closely linked, and deficits in these pathways are thought to occur in many neurodegenerative diseases. Astrocytes play important roles in both processes, and growing evidence suggests that neuron-astrocyte intercellular signalling ensures brain bioenergetic and redox homeostasis in health. Moreover, alterations to this crosstalk have been observed in the context of neurodegenerative pathology. In this review, we summarise the current understanding of how neuron-astrocyte interactions influence brain metabolism and antioxidant functions in health as well as during neurodegeneration. It is apparent that deleterious and adaptive protective responses alter brain metabolism in disease, and that knowledge of both may illuminate targets for future therapeutic interventions.
与生物能量学和氧化还原稳态相关的大脑代谢途径密切相关，人们认为许多神经退行性疾病中都会出现这些途径的缺陷。星形胶质细胞在这两个过程中都起着重要的作用，越来越多的证据表明，神经元-星形胶质细胞细胞间信号确保了大脑在健康状态下的生物能量学和氧化还原稳态。此外，在神经退行性病理的背景下已经观察到这种细胞间通讯的改变。在这篇综述中，我们总结了目前对于神经元-星形胶质细胞相互作用如何影响大脑代谢和抗氧化功能的理解，包括在健康状态和神经退行性变过程中的影响。显然，有害和适应性的保护反应会改变疾病状态下的大脑代谢，对这两方面的了解都可能为未来的治疗干预提供目标。
