Lambert P R, Palmer P E, Rubel E W
Arch Otolaryngol Head Neck Surg. 1986 Oct;112(10):1043-9. doi: 10.1001/archotol.1986.03780100031003.
The possible synergism between noise and aspirin for causing cochlear damage was examined histologically. Six chicks fed aspirin for five days and five chicks fed a normal diet only were paired and placed in sound chambers. They were exposed to a 1500-Hz tone at 115 dB sound pressure level for eight hours. The mean serum salicylate level just before noise exposure was 24 mg/dL (1.74 mmol/L). Ten days later they were killed, and the temporal bones were processed. Hair cell counts were made at 100-microns intervals throughout the length of the basilar papilla (cochlea). The noise produced a discrete cochlear lesion centered about 30% of the distance from the base to apex. The addition of aspirin did not significantly alter the extent or location of this lesion. One aspirin-fed chick had a unilateral middle ear effusion, and a striking shift in the center of damage toward the apex was noted in this cochlea.
从组织学角度研究了噪声与阿司匹林联合作用导致耳蜗损伤的可能性。将6只连续5天喂食阿司匹林的雏鸡和5只仅喂食正常饮食的雏鸡配对，放入隔音室。它们暴露于声压级为115分贝的1500赫兹纯音下8小时。噪声暴露前的平均血清水杨酸盐水平为24毫克/分升（1.74毫摩尔/升）。10天后将它们处死，处理颞骨。在整个基底乳头（耳蜗）长度上每隔100微米进行毛细胞计数。噪声产生了一个离散的耳蜗病变，位于从基底到顶端距离的约30%处。添加阿司匹林并未显著改变该病变的范围或位置。一只喂食阿司匹林的雏鸡出现单侧中耳积液，在该耳蜗中观察到损伤中心明显向顶端偏移。
