School of Chemistry, The University of New South Wales, Sydney, New South Wales, 2052, Australia.
School of Chemistry, The University of New South Wales, Sydney, New South Wales, 2052, Australia; Australia Centre for Nanomedicine, The University of New South Wales, Sydney, New South Wales, 2052, Australia.
Biosens Bioelectron. 2023 Oct 15;238:115577. doi: 10.1016/j.bios.2023.115577. Epub 2023 Aug 7.
Affinity biosensors play a crucial role in clinical diagnosis, pharmaceuticals, immunology, and other areas of human health. Affinity biosensors rely on the specific binding between target analytes and biological ligands such as antibodies, nucleic acids, aptamers, or other receptors to primarily generate electrochemical or optical signals. Considerable effort has been put into improving the performance of the affinity technologies to make them more sensitive, efficient and reproducible, of the many approaches electrokinetic phenomena are a viable option. In this perspective, studies that combine electrokinetic phenomena with affinity biosensor are discussed about their promise for achieving higher sensitivity and lower detection limit.
亲和生物传感器在临床诊断、制药、免疫学和人类健康的其他领域发挥着至关重要的作用。亲和生物传感器依赖于目标分析物与生物配体（如抗体、核酸、适体或其他受体）之间的特异性结合，主要产生电化学或光学信号。人们已经付出了相当大的努力来提高亲和技术的性能，使其更灵敏、高效和可重复，在许多方法中，电动现象是一种可行的选择。在这一观点中，讨论了将电动现象与亲和生物传感器结合的研究，以及它们在实现更高灵敏度和更低检测限方面的潜力。
