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COVID-19 出院后心血管和静脉血栓栓塞事件:一项前瞻性单中心研究。

Cardiovascular and Venous Thromboembolic Events After Hospital Discharge for COVID-19: A Prospective Single Center Study.

机构信息

Department of Vascular Medicine, CHU Amiens Picardie, Amiens, France.

EA CHIMERE, Université Picardie Jules Verne, Amiens, France.

出版信息

Angiology. 2024 Oct;75(9):893-898. doi: 10.1177/00033197231196175. Epub 2023 Aug 19.

Abstract

Coronavirus disease 2019 (COVID-19) is associated with an increase in venous thrombotic and cardiovascular (CV) events has been reported during hospitalization. No systematic ultrasound follow-up to evaluate sequelae was ever that took place carried out prospectively associated with the evaluation of CV morbidity-mortality at 3 months post-discharge. Consecutive patients hospitalized for COVID-19 in the Amiens-Picardie University Hospital between 1 February and 31 August 2020 were included. The primary objective was the thrombosis incidence at 3 months after hospital discharge. Thrombosis was defined as either venous thromboembolism (VTE) or a CV event (CVE: myocardial infarction (MI), stroke or peripheral arterial disease). A secondary objective was to determine the risk factors for thrombotic events. We included 498 patients (279 men; 56%) of median age 66 (55-76) years. The primary composite outcome occurred in 27 patients (5.4%); 19 patients (3.8%) presented a CVE (stroke, n = 5; MI, n = 9; and peripheral arterial disease, n = 5). Two patients (0.8%) presented VTE. Six patients (1.2%) died. In multivariate analysis, a previous CVE was associated with thrombosis (OR 3.11; 95% CI 1.17-8.24). COVID-19 was significantly associated with thrombotic events post hospital discharge. Special attention should be given to CVE in the follow-up of patients with a previous thrombotic event.

摘要

2019 年冠状病毒病(COVID-19)与住院期间静脉血栓形成和心血管(CV)事件的增加有关。在没有系统地进行前瞻性超声随访以评估与 3 个月出院后 CV 发病率-死亡率相关的后遗症的情况下。2020 年 2 月 1 日至 8 月 31 日,连续入住亚眠-皮卡第大学医院的 COVID-19 患者被纳入研究。主要目的是评估出院后 3 个月的血栓形成发生率。血栓形成定义为静脉血栓栓塞症(VTE)或 CV 事件(CVE:心肌梗死(MI)、中风或外周动脉疾病)。次要目的是确定血栓形成事件的危险因素。我们纳入了 498 名患者(279 名男性;56%),中位年龄 66(55-76)岁。主要复合结局发生在 27 名患者(5.4%)中;19 名患者(3.8%)出现 CVE(中风 n=5;MI n=9;外周动脉疾病 n=5)。2 名患者(0.8%)出现 VTE。6 名患者(1.2%)死亡。多变量分析显示,既往 CVE 与血栓形成相关(OR 3.11;95%CI 1.17-8.24)。COVID-19 与出院后血栓形成事件显著相关。在随访有既往血栓形成事件的患者时,应特别注意 CVE。

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